Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation (Q46226618)

20 December 2017

title

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation (English)

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20 December 2017

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Rafick-Pierre Sékaly

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object named as

Rafick Sekaly

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Amit Bar-or

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object named as

Amit Bar-Or

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Alexandre Prat

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object named as

Alexandre Prat

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author name string

Peter J Darlington

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Tarik Touil

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Jean-Sebastien Doucet

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Denis Gaucher

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Joumana Zeidan

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Dominique Gauchat

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Rachel Corsini

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Ho Jin Kim

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Martin Duddy

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Farzaneh Jalili

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Hania Kebir

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Jacqueline Chen

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Douglas L Arnold

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Marjorie Bowman

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Jack Antel

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Mark S Freedman

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Harold Atkins

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Remi Cheynier

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Canadian MS/BMT Study Group

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publication date

5 March 2013

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published in

Annals of Neurology

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volume

73

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issue

3

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page(s)

341-354

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Hematopoietic stem cell transplantation for multiple sclerosis. A retrospective multicenter study.

cites work

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High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis

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High-dose immunosuppression with autologous stem cell transplantation in severe refractory systemic lupus erythematosus.

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Myeloablative immunosuppressive treatment with autologous haematopoietic stem cell transplantation in a patient with psoriatic arthropathy and monoclonal gammopathy of undetermined significance

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Suppressing immunity in advancing MS: too much too late, or too late for much?

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The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience

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Multipotent mesenchymal stromal cells for autoimmune diseases: teaching new dogs old tricks.

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Characteristics of T-cell receptor repertoire and myelin-reactive T cells reconstituted from autologous haematopoietic stem-cell grafts in multiple sclerosis

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Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.

21 January 2018

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Immunological questions on hematopoietic stem cell transplantation for multiple sclerosis.

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T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

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IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

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T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

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Tracing functional antigen-specific CCR6 Th17 cells after vaccination

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

21 January 2018

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Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

21 January 2018

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Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles

21 January 2018

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T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.

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Immune ablation followed by autologous hematopoietic stem cell transplantation for the treatment of poor prognosis multiple sclerosis

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Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease

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Estimating thymic function through quantification of T-cell receptor excision circles

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Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis.

21 January 2018

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Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

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T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation

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Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

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Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology.

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Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: association with clinical and MRI activity

21 January 2018

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Reactivity pattern and cytokine profile of T cells primed by myelin peptides in multiple sclerosis and healthy individuals

21 January 2018

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Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study

21 January 2018

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Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS.

21 January 2018

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Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring

21 January 2018

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Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation

21 January 2018

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

21 January 2018

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Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease

21 January 2018

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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

21 January 2018

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CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis.

21 January 2018

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CCR6 regulates the migration of inflammatory and regulatory T cells

21 January 2018

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Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial

21 January 2018

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Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

21 January 2018

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Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.23784

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20 December 2017

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20 December 2017