Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. (Q46241349)

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17 January 2020

title

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis (English)

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17 January 2020

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10

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17 January 2020

Maria Bloksgaard

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17 January 2020

Pedro Luis Herrera

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Pierre Maechler

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17 January 2020

author name string

Stefania Carobbio

1

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17 January 2020

Francesca Frigerio

2

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17 January 2020

Blanca Rubi

3

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17 January 2020

Laurène Vetterli

4

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17 January 2020

Asllan Gjinovci

6

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17 January 2020

Shirin Pournourmohammadi

7

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17 January 2020

Walter Reith

9

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17 January 2020

language of work or name

English

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publication date

17 November 2008

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Journal of Biological Chemistry

17 January 2020

published in

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volume

284

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issue

2

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17 January 2020

page(s)

921-929

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

17 January 2020

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In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion

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Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

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L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

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Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

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Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

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Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

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The human glutamate dehydrogenase gene family: gene organization and structural characterization

21 January 2018

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Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene

21 January 2018

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The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

21 January 2018

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Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

21 January 2018

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The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

21 January 2018

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Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas

21 January 2018

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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Improved glucose tolerance in mice receiving intraperitoneal transplantation of normal fat tissue.

21 January 2018

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Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice

21 January 2018

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Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass

21 January 2018

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Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice

21 January 2018

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Utilization of fluorescence tracer in hyperinsulinemic-euglycemic clamp test in mice

21 January 2018

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Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

21 January 2018

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

21 January 2018

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Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

21 January 2018

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RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

21 January 2018

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Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue

21 January 2018

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Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase

21 January 2018

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Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M806295200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19015267%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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