Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells. (Q46256147)

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26 December 2019

title

Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells (English)

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26 December 2019

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4

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Jorgina Satrustegui Gil Delgado

26 December 2019

6

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26 December 2019

author name string

Patricia Mármol

1

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26 December 2019

Beatriz Pardo

2

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26 December 2019

Andreas Wiederkehr

3

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26 December 2019

Claes B Wollheim

5

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language of work or name

English

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publication date

7 November 2008

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Journal of Biological Chemistry

26 December 2019

published in

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26 December 2019

volume

284

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26 December 2019

issue

1

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page(s)

515-524

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Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell

26 December 2019

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Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain

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Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria

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Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria.

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Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle

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The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

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Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier

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Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

21 January 2018

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Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells

21 January 2018

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Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells

21 January 2018

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Pancreatic islet beta-cells transiently metabolize pyruvate

21 January 2018

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Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

21 January 2018

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Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

21 January 2018

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Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues

21 January 2018

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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

21 January 2018

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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

21 January 2018

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Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion

21 January 2018

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Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion

21 January 2018

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Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

21 January 2018

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The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia

21 January 2018

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21 January 2018

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Glucose-, calcium- and concentration-dependence of acetylcholine stimulation of insulin release and ionic fluxes in mouse islets

21 January 2018

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Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M806729200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18996845%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

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