Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate (Q46293337)

21 December 2017

title

Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate (English)

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21 December 2017

author name string

Hui Ding

1

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21 December 2017

Patrick L DeRoy

2

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Christian Perreault

3

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Alexandre Larivée

4

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Arshad Siddiqui

5

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Charles G Caldwell

6

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Susan Harran

7

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Patrick G Harran

8

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language of work or name

English

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publication date

26 February 2015

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21 December 2017

Angewandte Chemie International Edition

published in

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volume

54

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issue

16

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page(s)

4818-4822

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The biocatalytic repertoire of natural biaryl formation.

cites work

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Total Synthesis of Nominal Diazonamides-Part 1: Convergent Preparation of the Structure Proposed for (-)-Diazonamide A Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support),

21 January 2018

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Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Wel

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Chemistry and biology of diazonamide A: second total synthesis and biological investigations

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A Concise and Flexible Total Synthesis of (−)‐Diazonamide A

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21 January 2018

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21 January 2018

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An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center

21 January 2018

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An approach to the bis-oxazole macrocycle of diazonamides

21 January 2018

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The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product

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Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

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Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity

21 January 2018

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Mechanism for the direct synthesis of tryptophan from indole and serine: a useful NMR technique for the detection of a reactive intermediate in the reaction mixture

21 January 2018

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Mixed solvents containing methanol as useful reaction media for unique chemoselective reductions within lithium borohydride

21 January 2018

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Safe handling of cytotoxic compounds in a biopharmaceutical environment

21 January 2018

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Practical olefin aziridination with a broad substrate scope

21 January 2018

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Electrochemical enol ether/olefin cross-metathesis in a lithium perchlorate/nitromethane electrolyte solution

21 January 2018

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Total synthesis of dixiamycin B by electrochemical oxidation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201411663

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21 December 2017

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21 December 2017