Epidithiodioxopiperazines. occurrence, synthesis and biogenesis (Q26849609)

Robert M. Williams

series ordinal

2

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language of work or name

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October 2014

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published in

Natural Product Reports

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volume

31

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issue

10

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page(s)

1376-404

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Biosynthesis and function of gliotoxin in Aspergillus fumigatus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Structural relationship of epipolythiodioxopiperazines and their immunomodulating activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Studies on the Biosynthesis of Chetomin: Enantiospecific Synthesis of a Putative, Late-Stage Biosynthetic Intermediate

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Concise Total Synthesis of (+)-Bionectins A and C.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Enantioselective total synthesis of (-)-acetylaranotin, a dihydrooxepine epidithiodiketopiperazine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Total synthesis of epicoccin G.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Enantioselective total synthesis of (+)-gliocladine C: convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Total synthesis of (+)-11,11'-dideoxyverticillin A

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Chaetocochins A-C, epipolythiodioxopiperazines from Chaetomium cochliodes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Chaetomin, a New Antibiotic Substance Produced by Chaetomium cochliodes: I. Formation and Properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Antibacterial Activity of Sirodesmin PL Phytotoxin: Application to the Selection of Phytotoxin-Deficient Mutants

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

MPC1001 and its analogues: new antitumor agents from the fungus Cladorrhinum species

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Epicorazine C, an antimicrobial metabolite from Stereum hirsutum HKI 0195.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Redox sensitive epidithiodioxopiperazines in biological mechanisms of toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Immunosuppression in vitro by a metabolite of a human pathogenic fungus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Mechanism of action of gliotoxin: elimination of activity by sulfhydryl compounds

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Epipolythiopiperazinedione antibiotics from Penicillium turbatum

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

28 September 2017

https://api.crossref.org/works/10.1039%2FC3NP70097F

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

The protective effect of zinc sulphate in experimental sporidesmin poisoning of sheep

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Concise Total Synthesis of (+)-Gliocladins B and C

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Gliotoxin and related epipolythiodioxopiperazines

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Inhibition of c-fos proto-oncogene induction by Sch 52900 and Sch 52901, novel diketopiperazine produced by Gliocladium sp.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Inhibition by sporidesmin of hepatocyte bile acid transport

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

A total synthesis of sporidesmin A.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

A total synthesis of dehydrogliotoxin.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Antiviral agents. Chemical modifications of a disulfide antibiotic, acetylaranotin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Prevention of graft-versus-host disease by treatment of bone marrow with gliotoxin in fully allogeneic chimeras and their cytotoxic T cell repertoire

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Apoptosis induced in macrophages and T blasts by the mycotoxin sporidesmin and protection by Zn2+ salts

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

A total synthesis of gliotoxin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Total synthesis of (plus or minus) hyalodendrin.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Structures of novel epipolythiodioxopiperazines, emethallicins B, C, and D, potent inhibitors of histamine release, from Emericella heterothallica.

31 May 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Induction of apoptosis by T‐2 toxin and other natural toxins in HL‐60 human promyelotic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Nematicidal epipolysulfanyldioxopiperazines from Gliocladium roseum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

A tyrosine O-prenyltransferase catalyses the first pathway-specific step in the biosynthesis of sirodesmin PL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Identification of an agent in cultures of Aspergillus fumigatus displaying anti-phagocytic and immunomodulating activity in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4162872

Sporidesmium bakeri and Facial Eczema of Sheep in the Field

28 November 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

A Hepatotoxin from Sporidesmium bakeri capable of producing Facial Eczema Diseasesin Sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

Bionectins A−C, Epidithiodioxopiperazines with Anti-MRSA Activity, fromBionectra byssicolaF120

21 January 2018

1 reference

12 December 2020

Studies on fungal products. IX. Dethiosecoemestrin, a new metabolite related to emestrin, from Emericella striata

1 reference

12 December 2020

Biosynthesis of Gliotoxin and Mycelianamide

1 reference

12 December 2020

New verticillin and glisoprenin analogues from gliocladium catenulatum, a mycoparasite of aspergillus flavus sclerotia

1 reference

12 December 2020

The structure of chetomin

1 reference

12 December 2020

Studies on the mechanism of toxicity of the mycotoxin sporidesmin 3—inhibition by metals of the generation of superoxide radical by sporidesmin

1 reference

12 December 2020

Effects of gliotoxin and other sulfur-containing compounds on tumor cells in vitro; with observations on the mechanism of action of gliotoxin

1 reference

12 December 2020

GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin

1 reference

12 December 2020

The structure and absolute configuration of gliotoxin and the absolute configuration of sporidesmin

1 reference

12 December 2020

Sirodesmins A, B, C, and G, antiviral epipolythiopiperazine-2,5-diones of fungal origin: X-ray analysis of sirodesmin A diacetate

1 reference

12 December 2020

Studies on the metabolites of Verticillium sp. structures of Verticillins A, B, and C

1 reference

12 December 2020

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures

1 reference

12 December 2020

Hypoxia-inducible factor 1 inhibitors

1 reference

12 December 2020

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

1 reference

12 December 2020

Gliotoxin causes oxidative damage to plasmid and cellular DNA

1 reference

12 December 2020

Production, isolation, and antimicrobial activity of hyalodendrin, a new antibiotic produced by a species of Hyalodendron

1 reference

12 December 2020

LL-S88-alpha, an antiviral substance produced by Aspergillus terreus

1 reference

12 December 2020

Structure of a novel epidithiodioxopiperazine, emethallicin A, a potent inhibitor of histamine release from Emericella heterothallica

1 reference

12 December 2020

A novel class of diketopiperazines

1 reference

12 December 2020

New antibiotics from the fungus Epicoccum nigrum. II. Epicorazine A: Structure elucidation and absolute configuration

1 reference

12 December 2020

Total synthesis of (-)-acetylaranotin

1 reference

12 December 2020

New antibiotics from the fungus Epicoccum nigrum. III. Epicorazine B: Structure elucidation and absolute configuration

1 reference

12 December 2020

Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. I. Generation of superoxide radical by sporidesmin

1 reference

12 December 2020

[Isolation and configuration of Chaetocin]

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

Potent cytotoxic metabolites from a Leptosphaeria species. Structure determination and conformational analysis

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Total syntheses of chaetocin and ent-chaetocin

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Isolation of gliovictin from the marine deuteromycete Asteromyces cruciatus

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

THE STRUCTURE OF GLIOTOXIN

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericell striata

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Aurantioemestrin from Emericella striata and silvathione from Aspergillus silvaticus, possible key intermediates from epidithiodioxopiperazines to trioxopiperazines

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Novel epitetrathiodioxopiperazines, emethallicins B and C, as potent inhibitors of compound 48/80-induced histamine release, from Emericella heterothallica

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

cyclo-(L-Phenylalanyl-L-seryl) as an intermediate in the biosynthesis of gliotoxin

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Structure and synthesis of phomamide, a new piperazine-2,5-dione related to the sirodesmins, isolated from the culture medium of Phoma lingam Tode

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

New piperazinedione metabolites of Gliocladium deliquescens

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Studies on fungal products. Part 8. Isolation and structure of emestrin, a novel antifungal macrocyclic epidithiodioxopiperazine from Emericella striata. X-Ray molecular structure of emestrin

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Studies on fungal products. Part 13. Isolation and structures of dithiosilvatin and silvathione, novel dioxopiperazine derivatives from Aspergillus silvaticus

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

New co-metabolites of gliotoxin in Gliocladium virens

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Structure Revision and Cytotoxic Activity of the Scabrosin Esters, Epidithiopiperazinediones from the Lichen Xanthoparmelia scabrosa

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Gliotoxin-E: A New Biologically-Active Epipolythiodioxopiperazine Isolated From Penicillium terlikowskii

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Sirodesmin Biosynthesis

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Metabolites of Hyalodendron sp.: Bisdethiodi(methylthio)hyalodendrin

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Studies on fungal products. XIV. Emestrin B, a new epitrithiodioxopiperazine, from Emericella striata.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Chetracin A and chaetocins B and C, three new epipolythiodioxopiperazines from Chaetomium spp.

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Novel Epidithiodioxopiperazines, Emethallicins E and F, from Emericella heterothallica

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021

Studies of Fungal Products. XII. Structure of Aurantioemestrin from Emericella striata

1 reference

https://api.crossref.org/works/10.1039%2FC3NP70097F

7 January 2021