Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions (Q46299925)

21 December 2017

title

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions (English)

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21 December 2017

Stephen J Smerdon

7

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author name string

Jiejin Li

1

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21 December 2017

Ian A Taylor

2

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21 December 2017

Janette Lloyd

3

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21 December 2017

Julie A Clapperton

4

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21 December 2017

Steven Howell

5

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21 December 2017

Derek MacMillan

6

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21 December 2017

language of work or name

English

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publication date

23 October 2008

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21 December 2017

Journal of Biological Chemistry

published in

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21 December 2017

volume

283

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21 December 2017

issue

51

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21 December 2017

page(s)

36019-36030

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21 December 2017

https://api.crossref.org/works/10.1074%2FJBC.M804075200

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Caffeine inhibits the checkpoint kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Alternative splicing and mutation status of CHEK2 in stage III breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

21 January 2018

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Regulation of the Rad53 protein kinase in signal amplification by oligomer assembly and disassembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Autophosphorylated residues involved in the regulation of human chk2 in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Crystal Structure of a Phosphorylated Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Structure and regulation of the human Nek2 centrosomal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Probability-based protein identification by searching sequence databases using mass spectrometry data

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804075200

21 January 2018

Identifiers

DOI

10.1074/JBC.M804075200

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21 December 2017

PubMed ID

18948271

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21 December 2017