Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. (Q46363823)

21 December 2017

title

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. (English)

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21 December 2017

author name string

Weiqing Tang

1

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21 December 2017

Yinyan Ma

2

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21 December 2017

Lin Jia

3

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21 December 2017

Yiannis A Ioannou

4

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21 December 2017

Joanna P Davies

5

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21 December 2017

Liqing Yu

6

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21 December 2017

publication date

15 September 2008

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21 December 2017

Journal of Lipid Research

published in

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21 December 2017

volume

50

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21 December 2017

issue

2

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21 December 2017

page(s)

293-300

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21 December 2017

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

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Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters

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Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis

21 January 2018

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21 January 2018

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Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

21 January 2018

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

21 January 2018

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Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake

21 January 2018

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In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

21 January 2018

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Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

21 January 2018

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Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe

21 January 2018

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NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

21 January 2018

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Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles

21 January 2018

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Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane

21 January 2018

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NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells

21 January 2018

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

21 January 2018

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Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2.

21 January 2018

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Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

21 January 2018

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21 January 2018

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Selective sterol accumulation in ABCG5/ABCG8-deficient mice

21 January 2018

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Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice

21 January 2018

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Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol

21 January 2018

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Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion

21 January 2018

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Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis

21 January 2018

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Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

21 January 2018

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Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.

21 January 2018

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Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

21 January 2018

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Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice.

21 January 2018

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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

21 January 2018

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10.1194/JLR.M800439-JLR200

21 January 2018

Identifiers

DOI

1 reference

21 December 2017

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21 December 2017