Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. (Q46371654)

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19 March 2020

title

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages (English)

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19 March 2020

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1

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19 March 2020

Namiko Hoshi

2

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19 March 2020

Ruslan Medzhitov

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19 March 2020

author name string

Dror S Shouval

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19 March 2020

Scott Snapper

4

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19 March 2020

language of work or name

English

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publication date

1 May 2017

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19 March 2020

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19 March 2020

volume

356

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19 March 2020

page(s)

513-519

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19 March 2020

issue

6337

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Growth control under stress: mTOR regulation through the REDD1-TSC pathway

19 March 2020

cites work

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12 December 2020

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

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12 December 2020

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

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12 December 2020

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

12 December 2020

Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.

1 reference

12 December 2020

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.

1 reference

12 December 2020

Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production

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12 December 2020

T cell metabolism drives immunity

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

New insights into the molecular mechanism of interleukin-10-mediated immunosuppression

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12 December 2020

Metabolic regulation of immune responses

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12 December 2020

Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice.

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12 December 2020

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

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12 December 2020

Immunometabolism governs dendritic cell and macrophage function

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12 December 2020

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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12 December 2020

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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12 December 2020

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

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12 December 2020

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

1 reference

12 December 2020

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

1 reference

12 December 2020

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function

1 reference

12 December 2020

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production

1 reference

12 December 2020

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

1 reference

12 December 2020

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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12 December 2020

Mitochondria in the regulation of innate and adaptive immunity

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12 December 2020

mTOR signaling in growth control and disease

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12 December 2020

Function of mitochondrial Stat3 in cellular respiration

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12 December 2020

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation

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12 December 2020

Regulation and functions of the IL-10 family of cytokines in inflammation and disease

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12 December 2020

Sestrins orchestrate cellular metabolism to attenuate aging

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12 December 2020

Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease.

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12 December 2020

Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

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12 December 2020

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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12 December 2020

Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1.

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12 December 2020

Metabolic pathways in immune cell activation and quiescence

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12 December 2020

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

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12 December 2020

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

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12 December 2020

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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12 December 2020

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

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12 December 2020

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

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12 December 2020

Identifiers

DOI

10.1126/SCIENCE.AAL3535

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28473584%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28473584%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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