REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. (Q34092837)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25056877%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling (English)

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10 March 2020

3

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10 March 2020

author name string

Michael D Dennis

1

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10 March 2020

Catherine S Coleman

2

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10 March 2020

Leonard S Jefferson

4

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10 March 2020

Scot R Kimball

5

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10 March 2020

publication date

22 July 2014

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10 March 2020

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10 March 2020

volume

7

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10 March 2020

issue

335

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10 March 2020

page(s)

ra68

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

10 March 2020

cites work

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Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).

28 July 2018

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Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.

28 July 2018

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Sustained overexpression of Redd1 leads to Akt activation involved in cell survival

28 July 2018

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Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.

28 July 2018

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The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/β-catenin activity in zebrafish

28 July 2018

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Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor

28 July 2018

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

28 July 2018

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REDD1 protects osteoblast cells from gamma radiation-induced premature senescence

28 July 2018

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mTOR signaling in growth control and disease

28 July 2018

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28 July 2018

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Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2

28 July 2018

1 reference

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Determinants for Substrate Specificity of Protein Phosphatase 2A.

28 July 2018

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Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

28 July 2018

1 reference

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Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids

28 July 2018

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Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

28 July 2018

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Structural analysis and functional implications of the negative mTORC1 regulator REDD1

28 July 2018

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mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

28 July 2018

1 reference

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Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunit

28 July 2018

1 reference

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Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

28 July 2018

1 reference

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REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch

28 July 2018

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

28 July 2018

1 reference

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Human muscle gene expression following resistance exercise and blood flow restriction.

28 July 2018

1 reference

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4145530

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis

28 July 2018

1 reference

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

28 July 2018

1 reference

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AKT/PKB signaling: navigating downstream

28 July 2018

1 reference

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

28 July 2018

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Regulation of mTOR and cell growth in response to energy stress by REDD1.

28 July 2018

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Rheb binds and regulates the mTOR kinase

28 July 2018

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

28 July 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

28 July 2018

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

28 July 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

28 July 2018

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

28 July 2018

1 reference

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Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

28 July 2018

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The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

28 July 2018

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14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

28 July 2018

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REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

28 July 2018

1 reference

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Regulation of TSC2 by 14-3-3 binding

28 July 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

28 July 2018

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Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

28 July 2018

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Bidirectional modulation of insulin action by amino acids

28 July 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

28 July 2018

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Mechanism of activation of protein kinase B by insulin and IGF-1

28 July 2018

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The association between hematological and inflammatory factors and stress fractures among female military recruits.

28 July 2018

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

21 January 2018

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Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25056877

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2005103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25056877%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25056877%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference