Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway. (Q46384435)

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English	Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.	scientific article

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/15772344

Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway (English)

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12 May 2020

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12 May 2020

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Srinivasa Subramaniam

1

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12 May 2020

Neelam Shahani

2

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12 May 2020

Jens Strelau

3

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12 May 2020

Christine Laliberté

4

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12 May 2020

David Kaplan

6

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12 May 2020

Klaus Unsicker

7

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12 May 2020

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1 March 2005

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21 December 2017

http://europepmc.org/abstract/MED/15772344

Journal of Neuroscience

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12 May 2020

25

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11

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12 May 2020

2838-2852

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12 May 2020

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Vasopressin stimulates sodium transport in A6 cells via a phosphatidylinositide 3-kinase-dependent pathway

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Dual specificity phosphatases: a gene family for control of MAP kinase function.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

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MEK inhibitors block BDNF-dependent and -independent expression of GABA(A) receptor subunit mRNAs in cultured mouse cerebellar granule neurons

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Epidermal growth factor induces oxidative neuronal injury in cortical culture.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotrophin hypothesis for synaptic plasticity.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Regulation of Raf-Akt Cross-talk

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

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Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

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Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

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Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP.

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https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Akt is a molecular target for signal transduction therapy in brain ischemic insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic activation of ERK and neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and phosphatidylinositol 3-kinase pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging role for ERK as a key regulator of neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP-increasing agents interfere with chemoattractant-induced respiratory burst in neutrophils as a result of the inhibition of phosphatidylinositol 3-kinase rather than receptor-operated Ca2+ influx

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition by cAMP of Ras-dependent activation of Raf.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal g

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase inhibitor attenuates apoptotic cell death induced by amyloid beta protein in culture of the rat cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772344

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5060-04.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725128&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725128&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725128&resulttype=core&format=json

12 May 2020

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