Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation (Q46423291)

22 December 2017

title

Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation (English)

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22 December 2017

author name string

Zhi-Ying Chen

1

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22 December 2017

Efren Riu

2

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22 December 2017

Chen-Yi He

3

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22 December 2017

Hui Xu

4

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22 December 2017

Mark A Kay

5

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22 December 2017

publication date

5 February 2008

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22 December 2017

published in

Molecular Therapy

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22 December 2017

volume

16

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22 December 2017

issue

3

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22 December 2017

page(s)

548-556

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22 December 2017

Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

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Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo

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7 January 2021

Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

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Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

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Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

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High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter

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Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

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Complete and sustained phenotypic correction of hemophilia B in mice following hepatic gene transfer of a high-expressing human factor IX plasmid

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Long-term therapeutic levels of human alpha-1 antitrypsin in plasma after hydrodynamic injection of nonviral DNA.

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7 January 2021

In vitro and in vivo comparative study of chimeric liver-specific promoters

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7 January 2021

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

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7 January 2021

Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo

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7 January 2021

The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo

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7 January 2021

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

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7 January 2021

Reducing the immunostimulatory activity of CpG-containing plasmid DNA vectors for non-viral gene therapy

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7 January 2021

Toxicity of cationic lipid-DNA complexes

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7 January 2021

CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract

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7 January 2021

Contribution of Toll-like receptor 9 signaling to the acute inflammatory response to nonviral vectors

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7 January 2021

Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity

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7 January 2021

Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

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7 January 2021

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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7 January 2021

Reading the DNA methylation signal

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7 January 2021

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides

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7 January 2021

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

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7 January 2021

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

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7 January 2021

Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

The Ski protein family is required for MeCP2-mediated transcriptional repression

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

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7 January 2021

Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle

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7 January 2021

Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells

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7 January 2021

Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

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7 January 2021

Heterochromatin and epigenetic control of gene expression

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

HP1 and the dynamics of heterochromatin maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Gene activation and deactivation related changes in the three-dimensional structure of chromatin

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

RNA polymerase II elongation through chromatin

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300399

7 January 2021

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

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7 January 2021

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300399

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22 December 2017

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22 December 2017