Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli (Q46426199)

22 December 2017

title

Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli (English)

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22 December 2017

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Holtz MS

1

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22 December 2017

Forman SJ

series ordinal

2

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22 December 2017

Bhatia R

series ordinal

3

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22 December 2017

publication date

1 June 2005

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22 December 2017

published in

Leukemia

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22 December 2017

volume

19

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22 December 2017

issue

6

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22 December 2017

page(s)

1034-1041

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22 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403724

exact match

0 references

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Detection of BCR-ABL kinase mutations in CD34+ cells from chronic myelogenous leukemia patients in complete cytogenetic remission on imatinib mesylate treatment

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The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

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The tyrosine kinase inhibitor STI571, like interferon-alpha, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia

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7 January 2021

Apoptosis in chronic myeloid leukaemia: normal responses by progenitor cells to growth factor deprivation, X-irradiation and glucocorticoids

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Primary proliferating immature myeloid cells from CML patients are not resistant to induction of apoptosis by DNA damage and growth factor withdrawal

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Leukaemic blasts differ from normal bone marrow mononuclear cells and CD34+ haemopoietic stem cells in their metabolism of cytosine arabinoside

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The significance of bcr-abl molecular detection in chronic myeloid leukemia patients "late," 18 months or more after transplantation

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403724

1 reference

22 December 2017

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22 December 2017