Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau. (Q46448197)

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English	Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/15843619

Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau (English)

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12 May 2020

endoplasmic reticulum

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phosphorylation

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based on heuristic

inferred from title

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based on heuristic

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Frédéric Darios

1

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12 May 2020

author name string

Marie-Paule Muriel

2

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12 May 2020

Myriam Escobar Khondiker

3

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12 May 2020

Alexis Brice

4

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12 May 2020

Merle Ruberg

5

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12 May 2020

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publication date

1 April 2005

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Europe PubMed Central

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22 December 2017

http://europepmc.org/abstract/MED/15843619

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724963&resulttype=core&format=json

12 May 2020

25

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12 May 2020

16

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12 May 2020

4159-4168

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724963&resulttype=core&format=json

12 May 2020

Glutamate-induced neuron death requires mitochondrial calcium uptake

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Apoptosis driven by IP(3)-linked mitochondrial calcium signals

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https://pubmed.ncbi.nlm.nih.gov/15843619

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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https://pubmed.ncbi.nlm.nih.gov/15843619

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Mitochondria and calcium: from cell signalling to cell death

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Quantification of calcium signal transmission from sarco-endoplasmic reticulum to the mitochondria

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Ca(2+) dynamics in the lumen of the endoplasmic reticulum in sensory neurons: direct visualization of Ca(2+)-induced Ca(2+) release triggered by physiological Ca(2+) entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Mechanisms of neuronal cell death: diverse roles of calcium in the various subcellular compartments

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Glutamate decreases mitochondrial size and movement in primary forebrain neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Endoplasmic reticulum Ca(2+) homeostasis and neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Stable-tau overexpression in human neuroblastoma cells: an open door for explaining neuronal death in tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Mitochondrial stop and go: signals that regulate organelle movement

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein as a differential biomarker of tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decoding of cytosolic calcium oscillations in the mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide induces apoptosis in cultured mesencephalic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by cdk5 decreases its microtubule nucleation activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

based on heuristic

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Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

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https://pubmed.ncbi.nlm.nih.gov/15843619

12 December 2020

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Identifiers

10.1523/JNEUROSCI.0060-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724963&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724963&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724963&resulttype=core&format=json

12 May 2020

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