Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells (Q46463187)

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scientific article published on 25 July 2008

Language	Label	Description	Also known as
English	Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells	scientific article published on 25 July 2008

Statements

scholarly article

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells (English)

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

multiple drug resistance

1 reference

based on heuristic

inferred from title

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based on heuristic

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author name string

Hong Li

1

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Hyo-Eon Jin

2

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Wooyoung Kim

3

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Yong-Hae Han

4

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Dae-Duk Kim

5

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Suk-Jae Chung

6

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Chang-Koo Shim

7

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

publication date

25 July 2008

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Pharmaceutical Research

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Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

25

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Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

11

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Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

2601-2612

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor

1 reference

https://api.crossref.org/works/10.1007%2FS11095-008-9678-0

21 January 2018

Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The S-phase cytotoxicity of camptothecin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple and sensitive high performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of topotecan in human plasma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of probenecid on the biliary excretion of belotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transport of a reversible proton pump antagonist, 5, 6-dimethyl-2-(4-Fluorophenylamino)-4-(1-methyl-1,2,3, 4-tetrahydroisoquinoline-2-yl) pyrimidine hydrochloride (YH1885), across caco-2 cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simple and sensitive determination of the new antitumor drug CKD-602 in human plasma by liquid chromatography.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The current status of camptothecin analogues as antitumor agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral topotecan given once or twice daily for ten days: a phase I pharmacology study in adult patients with solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport characteristics of fexofenadine in the Caco-2 cell model

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interpatient variability in bioavailability of the intravenous formulation of topotecan given orally to children with recurrent solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of P-glycoprotein in biliary excretion of CPT-11 in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intestinal absorption of camptothecin, a highly lipophilic drug, across Caco-2 cells is mediated by active transporter(s)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of orally administered camptothecins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical and phase I clinical studies with Ckd-602, a novel camptothecin derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cyclosporin A and verapamil on the intracellular daunorubicin accumulation in Chinese hamster ovary cells with increasing levels of drug-resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan

1 reference

https://pubmed.ncbi.nlm.nih.gov/18654741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-008-9678-0

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

1 reference

Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/18654741

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