Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit (Q46525133)

22 December 2017

title

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit (English)

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22 December 2017

author name string

S Chandra Shekar

1

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22 December 2017

Haiyan Wu

2

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22 December 2017

Zheng Fu

3

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22 December 2017

Shu-Chin Yip

4

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22 December 2017

Nagajyothi

5

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22 December 2017

Sean M Cahill

6

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22 December 2017

Mark E Girvin

7

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22 December 2017

Jonathan M Backer

8

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22 December 2017

language of work or name

English

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publication date

2 June 2005

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22 December 2017

Journal of Biological Chemistry

published in

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22 December 2017

volume

280

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22 December 2017

page(s)

27850-27855

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22 December 2017

issue

30

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22 December 2017

cites work

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

A new nomenclature for int-1 and related genes: the Wnt gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Rho family GTPases bind to phosphoinositide kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

NMR View: A computer program for the visualization and analysis of NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Improved 1HN-detected triple resonance TROSY-based experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

The Xplor-NIH NMR molecular structure determination package

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

PKA: a portrait of protein kinase dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Mapping protein-protein interactions in solution by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Direct Determination of Changes of Interdomain Orientation on Ligation: Use of the Orientational Dependence of15N NMR Relaxation in Abl SH(32)†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506005200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506005200

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22 December 2017

PubMed ID

15932879

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22 December 2017