ATPase phospholipid transporting 8B1 (Q4654859)

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mammalian protein found in Homo sapiens

ATP8B1
familial intrahepatic cholestasis type 1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
P4-ATPase flippase complex alpha subunit ATP8B1
ATPase, class I, type 8B, member 1
ATPase class I type 8B member 1
probable phospholipid-transporting ATPase IC
E1-E2 ATPase
phospholipid-transporting ATPase IC

Language	Label	Description	Also known as
English	ATPase phospholipid transporting 8B1	mammalian protein found in Homo sapiens	ATP8B1 familial intrahepatic cholestasis type 1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 P4-ATPase flippase complex alpha subunit ATP8B1 ATPase, class I, type 8B, member 1 ATPase class I type 8B member 1 probable phospholipid-transporting ATPase IC E1-E2 ATPase phospholipid-transporting ATPase IC

Statements

1 reference

20 December 2017

UniProt protein ID

P-type ATPase, A domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

P-type ATPase, cytoplasmic domain N

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

P-type ATPase, transmembrane domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

Phospholipid-transporting ATPase IC

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

HAD-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

P-type ATPase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

P-type ATPase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

20 December 2017

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

molecular function

cardiolipin binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

lipid transporter activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

protein binding

determination method

3 references

9 May 2019

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

ATPase-coupled intramembrane lipid transporter activity

determination method

5 references

16 July 2018

FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

hydrolase activity

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

magnesium ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

aminophospholipid flippase activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

ATPase-coupled intramembrane lipid transporter activity

determination method

5 references

9 May 2019

FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

cell projection

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

plasma membrane

determination method

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

16 July 2018

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O43520&geneProductId=UniProtKB:O43520

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

brush border membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

apical plasma membrane

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

Golgi apparatus

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

plasma membrane

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

biological process

regulation of microvillus assembly

determination method

1 reference

9 May 2019

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

lipid transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

Golgi organization

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

xenobiotic transmembrane transport

determination method

1 reference

9 May 2019

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

bile acid metabolic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

phospholipid transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

ion transmembrane transport

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

inner ear receptor cell development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

phospholipid translocation

determination method

bile acid and bile salt transport

determination method

1 reference

9 May 2019

FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

vestibulocochlear nerve formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

aminophospholipid transport

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

phospholipid translocation

determination method

3 references

9 May 2019

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43520

determination method

Gene Atlas image

PBB GE ATP8B1 214594 x at fs.png
732 × 530; 12 KB

0 references

P-type ATPase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

P-type ATPase, phosphorylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

P-type ATPase, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O43520

Identifiers

RefSeq protein ID

1 reference

18 May 2018

1 reference

18 May 2018

1 reference

18 May 2018

UniProt protein ID

1 reference

20 December 2017

UniProt protein ID

Ensembl protein ID

ENSP00000283684

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000283684

ENSP00000467767

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000467767

ENSP00000468266

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000468266

ENSP00000468751

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000468751

ENSP00000494712

1 reference

ensembl Release 92

Ensembl protein ID

ENSP00000494712

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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