CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells (Q24315876)

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4 February 2020

title

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells (English)

1 reference

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Transmembrane protein 30B

4 February 2020

main subject

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Transmembrane protein 30A

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ATPase phospholipid transporting 8B1

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phospholipid translocation

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ATPase, class I, type 8B, member 1

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author

Francisco Muñoz-Martínez

1

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4 February 2020

Santiago Castanys

3

1 reference

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4 February 2020

Francisco Gamarro

4

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4 February 2020

author name string

Cristina Torres

2

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4 February 2020

language of work or name

English

0 references

publication date

25 May 2010

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4 February 2020

published in

Biochemical Pharmacology

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4 February 2020

volume

80

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4 February 2020

issue

6

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4 February 2020

page(s)

793-800

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Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport

4 February 2020

cites work

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Inward translocation of the phospholipid analogue miltefosine across Caco-2 cell membranes exhibits characteristics of a carrier-mediated process

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Perifosine: update on a novel Akt inhibitor.

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The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease

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P4 ATPases - lipid flippases and their role in disease

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The yeast plasma membrane P4-ATPases are major transporters for lysophospholipids

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The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

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Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells

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Aberrant termination of reproduction-related TMEM30C transcripts in the hominoids.

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Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

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Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

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Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p

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Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis

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Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine

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Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae

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A human cell line from a pleural effusion derived from a breast carcinoma

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Breast tumor cell lines from pleural effusions

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Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

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7 January 2021

Pharmacodynamic markers of perifosine efficacy

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A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells

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Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

1752404

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510206%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1752404

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1752404