Molecular framework for the activation of RNA-dependent protein kinase (Q46581088)

23 December 2017

title

Molecular framework for the activation of RNA-dependent protein kinase (English)

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23 December 2017

author

Sean A. McKenna

1

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23 December 2017

author name string

Darrin A Lindhout

2

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Insil Kim

3

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Corey W Liu

4

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Vladimir M Gelev

5

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Gerhard Wagner

6

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Joseph D Puglisi

7

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language of work or name

English

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publication date

6 February 2007

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Journal of Biological Chemistry

published in

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volume

282

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issue

15

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page(s)

11474-11486

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23 December 2017

Induction and regulation of IFNs during viral infections

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Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance

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Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

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HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.

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The dsRNA binding protein family: critical roles, diverse cellular functions

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Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

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Mechanism of interferon action motif I of the interferon-induced, RNA-dependent protein kinase (PKR) is sufficient to mediate RNA-binding activity

21 January 2018

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Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.

21 January 2018

1 reference

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Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

21 January 2018

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Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

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Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).

21 January 2018

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Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA.

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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

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Molecular basis for PKR activation by PACT or dsRNA

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Unactivated PKR exists in an open conformation capable of binding nucleotides

21 January 2018

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Autophosphorylation kinetics of protein kinases

21 January 2018

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Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.

21 January 2018

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Phosphorylation of the RNA-dependent protein kinase regulates its RNA-binding activity

21 January 2018

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Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

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Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase

21 January 2018

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Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

21 January 2018

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Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

21 January 2018

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1H, 13C, 15N resonance assignment of the 20 kDa double stranded RNA binding domain of PKR

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M700301200

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23 December 2017

PubMed ID

17284445

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23 December 2017