Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). (Q39417308)

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scientific article published on July 2001

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English	Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).	scientific article published on July 2001

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scholarly article

1 reference

Europe PubMed Central

11 September 2017

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). (English)

1 reference

Europe PubMed Central

11 September 2017

phosphorylation

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based on heuristic

inferred from title

author name string

K M Vattem

1

1 reference

Europe PubMed Central

11 September 2017

K A Staschke

2

1 reference

Europe PubMed Central

11 September 2017

R C Wek

3

1 reference

Europe PubMed Central

11 September 2017

language of work or name

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publication date

1 July 2001

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Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

268

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Europe PubMed Central

11 September 2017

13

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Europe PubMed Central

11 September 2017

3674-3684

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Europe PubMed Central

11 September 2017

PKR: a new name and new roles.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

eIF-2 kinases: regulators of general and gene-specific translation initiation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

1 reference

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21 January 2018

Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

PKR; a sentinel kinase for cellular stress

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeast

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

1 reference

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21 January 2018

Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR).

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1 reference

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21 January 2018

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Glutathione S-transferase can be used as a C-terminal, enzymatically active dimerization module for a recombinant protease inhibitor, and functionally secreted into the periplasm of Escherichia coli

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

RNA recognition by a Staufen double-stranded RNA-binding domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.02273.X

21 January 2018

Rapid decrease in the levels of the double-stranded RNA-dependent protein kinase during virus infections

1 reference

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21 January 2018

Identifiers

10.1046/J.1432-1327.2001.02273.X

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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