PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor (Q46643213)

23 December 2017

title

PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor (English)

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23 December 2017

author

Jean Feuillard

12

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23 December 2017

Nathanael Larochette

Nathanael Larochette

6

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Mojgan Djavaheri-Mergny

Mojgan Djavaheri-Mergny

8

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Jean-Luc Perfettini

Jean-Luc Perfettini

7

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Guido Kroemer

13

Guido Kroemer

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23 December 2017

10

Patrice Codogno

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23 December 2017

author name string

Rosa-Ana Gonzalez-Polo

1

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23 December 2017

Gabrielle Carvalho

2

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23 December 2017

Thorsten Braun

3

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23 December 2017

Didier Decaudin

4

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23 December 2017

Claire Fabre

5

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23 December 2017

Ibtissam Youlyouz-Marfak

9

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23 December 2017

Martine Raphael

11

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23 December 2017

language of work or name

English

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publication date

1 November 2005

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23 December 2017

published in

Oncogene

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23 December 2017

volume

24

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23 December 2017

issue

51

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23 December 2017

page(s)

7503-7513

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23 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208907

exact match

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cites work

Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation

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Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species

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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

21 January 2018

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PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

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Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

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Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

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Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

21 January 2018

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Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway

21 January 2018

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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1.

21 January 2018

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Pilot Study of PK 11195, a Selective Ligand for the Peripheral-Type Benzodiazepine Binding Sites, in Inpatients with Anxious or Depressive Symptomatology

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7 January 2021

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

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7 January 2021

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

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7 January 2021

Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells

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Peripheral benzodiazepine receptor and its clinical targeting

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7 January 2021

The pathophysiology of mitochondrial cell death

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7 January 2021

Evidence in favour of a role for peripheral-type benzodiazepine receptor ligands in amplification of neuronal apoptosis

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Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.

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Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

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7 January 2021

The peripheral benzodiazepine receptor ligand PK11195 overcomes different resistance mechanisms to sensitize AML cells to gemtuzumab ozogamicin

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7 January 2021

Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208907

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208907

1 reference

23 December 2017

PubMed ID

16091749

1 reference

23 December 2017