Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. (Q46675912)

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6 January 2020

title

Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes (English)

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6 January 2020

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3

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6 January 2020

Peter Strålfors

series ordinal

4

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6 January 2020

author name string

Anna Danielsson

series ordinal

1

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6 January 2020

Anita Ost

series ordinal

2

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6 January 2020

language of work or name

English

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publication date

29 August 2005

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Journal of Biological Chemistry

6 January 2020

number of pages

4

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based on heuristic

inferred from page(s)

published in

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6 January 2020

volume

280

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6 January 2020

page(s)

34389-34392

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6 January 2020

issue

41

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Insulin signalling and the regulation of glucose and lipid metabolism

6 January 2020

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Turning down insulin signaling.

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Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes.

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

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Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies

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Impact of natural IRS-1 mutations on insulin signals: mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling

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The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells

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A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.

21 January 2018

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

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Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

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Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

21 January 2018

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Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

21 January 2018

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Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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Restraining PI3K: mTOR signalling goes back to the membrane.

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Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

21 January 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity.

21 January 2018

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Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

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21 January 2018

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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

21 January 2018

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Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.C500230200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16129690%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference