Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents. (Q46681409)

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6 January 2020

title

Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents (English)

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6 January 2020

author

Dorothy M Jones-Davis

1

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6 January 2020

author name string

Luyan Song

2

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6 January 2020

Martin J Gallagher

3

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6 January 2020

Robert L Macdonald

4

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language of work or name

English

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publication date

1 August 2005

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6 January 2020

published in

Journal of Neuroscience

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6 January 2020

volume

25

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6 January 2020

issue

35

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6 January 2020

page(s)

8056-8065

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Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide.

6 January 2020

cites work

1 reference

12 December 2020

Structure-function relationships of the human glycine receptor: insights from hyperekplexia mutations.

1 reference

12 December 2020

Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: three residues are required for allosteric coupling.

1 reference

12 December 2020

A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics

1 reference

12 December 2020

Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor

1 reference

12 December 2020

Arg-274 and Leu-277 of the gamma-aminobutyric acid type A receptor alpha 2 subunit define agonist efficacy and potency

1 reference

12 December 2020

Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

1 reference

12 December 2020

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

1 reference

12 December 2020

Two gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptors

1 reference

12 December 2020

The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state.

1 reference

12 December 2020

First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene

1 reference

12 December 2020

Mutagenesis of the GABA(A) receptor alpha1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine-site ligands

1 reference

12 December 2020

Agonist Trapping by GABAA Receptor Channels.

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12 December 2020

Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits.

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12 December 2020

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

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12 December 2020

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

1 reference

12 December 2020

Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement

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12 December 2020

Coupling of agonist binding to channel gating in the GABA(A) receptor

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12 December 2020

Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity

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12 December 2020

Structure and gating mechanism of the acetylcholine receptor pore

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12 December 2020

Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

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12 December 2020

Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates

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12 December 2020

Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

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12 December 2020

GABAA receptor channels

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12 December 2020

Assembly of GABAA receptor subunits: role of the delta subunit

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12 December 2020

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.

1 reference

12 December 2020

Characterisation of δ-subunit containing GABAA receptors from rat brain

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12 December 2020

Functional domains of GABAA receptors.

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12 December 2020

Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique.

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12 December 2020

A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy

1 reference

12 December 2020

Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits

1 reference

12 December 2020

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

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12 December 2020

Stoichiometry of a recombinant GABAA receptor.

1 reference

12 December 2020

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1 reference

12 December 2020

Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation

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12 December 2020

Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors

1 reference

12 December 2020

Slow-channel transgenic mice: a model of postsynaptic organellar degeneration at the neuromuscular junction.

1 reference

12 December 2020

The benzodiazepine binding site of GABAA receptors

1 reference

12 December 2020

Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.

1 reference

12 December 2020

10.1523/JNEUROSCI.0348-05.2005

Identifiers

DOI

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6 January 2020

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6 January 2020

PubMed publication ID

16135763

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