The DEBS paradigm for type I modular polyketide synthases and beyond (Q46773244)

25 December 2017

title

The DEBS paradigm for type I modular polyketide synthases and beyond (English)

1 reference

25 December 2017

author name string

Leonard Katz

series ordinal

1

1 reference

25 December 2017

language of work or name

English

0 references

publication date

1 January 2009

1 reference

25 December 2017

published in

Methods in Enzymology

1 reference

25 December 2017

volume

459

1 reference

25 December 2017

page(s)

113-142

1 reference

25 December 2017

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Iterative chain elongation by a pikromycin monomodular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A chain initiation factor common to both modular and aromatic polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A cryptic PKS–NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

LL-F28249 antibiotic complex: A new family of antiparastic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 .ALPHA., .BETA., .GAMMA., .LAMBDA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermecti

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Modular organization of genes required for complex polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

GNAT-like strategy for polyketide chain initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Molecular basis of celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Analysis of the ambruticin and jerangolid gene clusters of Sorangium cellulosum reveals unusual mechanisms of polyketide biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Translation and protein synthesis: macrolides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

New rapamycin derivatives by precursor-directed biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Engineering broader specificity into an antibiotic-producing polyketide synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA polymerase inhibitor from the myxobacterium Sorangium cellulosum.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Biosynthesis and attachment of novel bacterial polyketide synthase starter units

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055Cluster Analysis and Assignment of Functions

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A hybrid modular polyketide synthase obtained by domain swapping

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Identification of the bkdAB gene cluster, a plausible source of the starter-unit for virginiamycin M production in Streptomyces virginiae.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

3-Hydroxy-3-Methylglutaryl-CoA-Like Synthases Direct the Formation of Methyl and Ethyl Side Groups in the Biosynthesis of the Antibiotic Myxovirescin A

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The type I fatty acid and polyketide synthases: a tale of two megasynthases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Cloning and heterologous expression of the epothilone gene cluster.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Elucidating the mechanism of cis double bond formation in epothilone biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Analysis of modular-iterative mixed biosynthesis of lankacidin by heterologous expression and gene fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The structural basis for docking in modular polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Origin of starter units for erythromycin biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904606-0

7 January 2021

10.1016/S0076-6879(09)04606-0

Identifiers

DOI

1 reference

25 December 2017

PubMed ID

19362638

1 reference

25 December 2017