Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. (Q46832912)

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5 January 2020

title

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes (English)

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1

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John R Carney

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author name string

Ralph Reid

2

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5 January 2020

Sunil S Chandran

4

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5 January 2020

Sarah J Reisinger

5

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5 January 2020

Kedar G Patel

6

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David A Hopwood

7

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Daniel V Santi

8

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publication date

14 August 2005

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volume

23

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issue

9

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page(s)

1171-1176

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https://scigraph.springernature.com/pub.10.1038/nbt1128

5 January 2020

exact match

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cites work

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The enzymology of combinatorial biosynthesis

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Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

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Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

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Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production

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Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis

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Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity

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Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

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An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

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7 January 2021

A hybrid modular polyketide synthase obtained by domain swapping

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7 January 2021

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

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7 January 2021

Engineered intermodular and intramodular polyketide synthase fusions

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7 January 2021

Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase

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7 January 2021