Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway (Q46791877)

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scientific article published on 13 June 2013

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English	Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway	scientific article published on 13 June 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/23761018

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway (English)

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/23761018

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Qing-Long Guo

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25 December 2017

http://europepmc.org/abstract/MED/23761018

author name string

Hu Wang

1

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Li Zhao

2

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Li-Tao Zhu

3

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Yu Wang

4

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Di Pan

5

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Jing Yao

6

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Qi-Dong You

7

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25 December 2017

http://europepmc.org/abstract/MED/23761018

publication date

13 June 2013

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25 December 2017

http://europepmc.org/abstract/MED/23761018

Molecular Carcinogenesis

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25 December 2017

http://europepmc.org/abstract/MED/23761018

53 Suppl 1

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25 December 2017

http://europepmc.org/abstract/MED/23761018

E107-18

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PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/23761018

Effect of hypoxia-inducible factor-1alpha silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide

1 reference

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Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

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Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation

1 reference

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Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism.

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Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity

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Oroxylin A reverses multi-drug resistance of human hepatoma BEL7402/5-FU cells via downregulation of P-glycoprotein expression by inhibiting NF-κB signaling pathway.

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Reversal of p-glycoprotein-mediated multidrug resistance by macrocyclic bisbibenzyl derivatives in adriamycin-resistant human myelogenous leukemia (K562/A02) cells

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Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

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Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning

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21 January 2018

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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21 January 2018

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes

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Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines

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A randomized controlled trial comparing mupirocin and polysporin triple ointments in peritoneal dialysis patients: the MP3 Study

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Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

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Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies

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21 January 2018

Hypoxia signalling controls metabolic demand

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21 January 2018

Developmental toxicity and genotoxicity studies of wogonin.

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21 January 2018

Glycolysis inhibition for anticancer treatment

1 reference

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21 January 2018

Identifiers

10.1002/MC.22052

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/23761018

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/23761018

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