Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients (Q46801587)

25 December 2017

title

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients (English)

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25 December 2017

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6

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author name string

D Cozzone

1

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S Fröjdö

2

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E Disse

3

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C Debard

4

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M Laville

5

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H Vidal

7

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publication date

18 January 2008

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25 December 2017

published in

Diabetologia

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volume

51

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page(s)

512-521

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issue

3

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25 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-007-0913-8

exact match

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cites work

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Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

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Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle

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12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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12 December 2020

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

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12 December 2020

Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

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12 December 2020

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

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12 December 2020

Role of Akt/protein kinase B in metabolism.

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12 December 2020

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

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12 December 2020

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease

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12 December 2020

Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients

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12 December 2020

Synergistic interaction between exercise and insulin on peripheral glucose uptake

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12 December 2020

Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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12 December 2020

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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12 December 2020

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects.

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12 December 2020

Structure, regulation and function of PKB/AKT--a major therapeutic target

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12 December 2020

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families

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Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms

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Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

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12 December 2020

Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation

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12 December 2020

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

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12 December 2020

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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12 December 2020

Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes.

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12 December 2020

The insulin signalling system and the IRS proteins

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12 December 2020

The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity

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12 December 2020

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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12 December 2020

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

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12 December 2020

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

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12 December 2020

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

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12 December 2020

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

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12 December 2020

Protein kinase B/Akt at a glance

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12 December 2020

10.1007/S00125-007-0913-8

Identifiers

DOI

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25 December 2017

PubMed ID

18204829

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25 December 2017