Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. (Q46807874)

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9 January 2020

title

Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines (English)

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John Atack

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author name string

Rebecca Dias

1

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Wayne F A Sheppard

2

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Rosa L Fradley

3

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Elizabeth M Garrett

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Spencer J Tye

6

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Simon Goodacre

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Rachael J Lincoln

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Susan M Cook

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Rachel Conley

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David Hallett

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Alexander C Humphries

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Sally A Thompson

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Keith A Wafford

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Leslie J Street

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J Luis Castro

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Paul J Whiting

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Thomas W Rosahl

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Ruth M McKernan

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Gerard R Dawson

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David S Reynolds

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language of work or name

English

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publication date

1 November 2005

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9 January 2020

published in

Journal of Neuroscience

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volume

25

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issue

46

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page(s)

10682-10688

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Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

9 January 2020

cites work

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12 December 2020

The neuroanatomical and neurochemical basis of conditioned fear.

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12 December 2020

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

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12 December 2020

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

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Molecular and neuronal substrate for the selective attenuation of anxiety.

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GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

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The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament

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GABA(A) receptor subtypes: dissecting their pharmacological functions

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Anxiolytic-like action of diazepam: which GABA(A) receptor subtype is involved?

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12 December 2020

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

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12 December 2020

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

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12 December 2020

Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors

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12 December 2020

Stress-induced hyperthermia and anxiety: pharmacological validation

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12 December 2020

Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety

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12 December 2020

Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies

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12 December 2020

Psychological stress and body temperature changes in humans

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12 December 2020

Modifying quinolone antibiotics yields new anxiolytics

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12 December 2020

Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes

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12 December 2020

Functional mapping of GABA A receptor subtypes in the amygdala

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12 December 2020

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors

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12 December 2020

The benzodiazepine binding site of GABA A receptors as a target for the development of novel anxiolytics

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12 December 2020

Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.

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12 December 2020

Type I and type II GABAA-benzodiazepine receptors produced in transfected cells

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12 December 2020

The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines.

1 reference

12 December 2020

Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]

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12 December 2020

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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12 December 2020

Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors

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12 December 2020

Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.

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12 December 2020

10.1523/JNEUROSCI.1166-05.2005

Identifiers

DOI

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