Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains (Q46808331)

25 December 2017

title

Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains (English)

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2

Ina L Urbatsch

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25 December 2017

author name string

Jyh-Yeuan Lee

series ordinal

1

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Alan E Senior

series ordinal

3

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Stephan Wilkens

series ordinal

4

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language of work or name

English

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publication date

5 August 2002

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Journal of Biological Chemistry

published in

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volume

277

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issue

42

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page(s)

40125-40131

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ABC Transporters: From Microorganisms to Man

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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Biochemistry of multidrug resistance mediated by the multidrug transporter

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ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

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The catalytic cycle of P-glycoprotein

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites.

21 January 2018

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Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

21 January 2018

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Crystal structure of the ATP-binding subunit of an ABC transporter

21 January 2018

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Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

21 January 2018

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The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

21 January 2018

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Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

21 January 2018

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

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Is the multidrug transporter a flippase?

21 January 2018

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

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Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells

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Amphipols: polymers that keep membrane proteins soluble in aqueous solutions

21 January 2018

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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Two-dimensional crystallization on lipid layer: A successful approach for membrane proteins

21 January 2018

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A new generation of the IMAGIC image processing system

21 January 2018

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Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

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Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

21 January 2018

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Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

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Two-dimensional crystallization of a membrane protein on a detergent-resistant lipid monolayer 1 1Edited by R. Huber

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M206871200

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25 December 2017

PubMed ID

12163504

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25 December 2017