A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage (Q46814157)

25 December 2017

title

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage (English)

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25 December 2017

author name string

Ming-Tain Lai

1

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25 December 2017

Ming-Chih Crouthamel

2

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25 December 2017

Jillian DiMuzio

3

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25 December 2017

Beth Lynn Pietrak

4

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25 December 2017

Dorit B Donoviel

5

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25 December 2017

Alan Bernstein

6

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25 December 2017

Stephen J Gardell

7

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25 December 2017

Yue-Ming Li

8

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25 December 2017

Daria Hazuda

9

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25 December 2017

language of work or name

English

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publication date

21 November 2005

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25 December 2017

Journal of Neurochemistry

published in

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25 December 2017

volume

96

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25 December 2017

issue

1

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25 December 2017

page(s)

118-125

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25 December 2017

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: detection by liquid phase electrochemiluminescent system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Correlation between beta-amyloid peptide production and human APP-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Presenilins are not required for A beta 42 production in the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Mechanisms of pH regulation in the regulated secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2005.03528.X

10.1111/J.1471-4159.2005.03528.X

21 January 2018

Identifiers

DOI

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25 December 2017

release_l5344rqvsnhlllqx5x2sffgviu

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https://api.fatcat.wiki/v0/release/l5344rqvsnhlllqx5x2sffgviu

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25 December 2017