Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. (Q46847084)

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29 December 2019

title

Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152 (English)

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7

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Yungan Tao

1

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29 December 2019

Ping Zhang

2

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Maria Castedo

5

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29 December 2019

Eric Deutsch

8

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29 December 2019

author name string

F Girdler

3

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V Frascogna

4

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29 December 2019

J Bourhis

6

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language of work or name

English

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publication date

17 December 2007

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volume

27

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issue

23

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page(s)

3244-3255

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210990

29 December 2019

exact match

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cites work

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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The cellular geography of aurora kinases

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts

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Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

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Validating Aurora B as an anti-cancer drug target.

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The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

21 January 2018

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

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Cell-cycle checkpoints and cancer

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

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Aurora-kinase inhibitors as anticancer agents

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

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Mitotic kinases as regulators of cell division and its checkpoints

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BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

21 January 2018

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Role of cell cycle in mediating sensitivity to radiotherapy

21 January 2018

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

21 January 2018

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AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

21 January 2018

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Caspase independence of radio-induced cell death

21 January 2018

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1210990

1 reference

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29 December 2019

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