Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors. (Q46865333)

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scientific article published on 4 December 2007

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English	Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors.	scientific article published on 4 December 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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quantitative structure-activity relationship

1 reference

based on heuristic

inferred from title

Prashant S Kharkar

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

author name string

Maarten E A Reith

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

publication date

4 December 2007

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29 December 2019

Journal of Computer - Aided Molecular Design

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

22

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1-17

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PET studies of brain monoamine transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060532

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The selective norepinephrine reuptake inhibitor antidepressant reboxetine: pharmacological and clinical profile.

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Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.

1 reference

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Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats

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Serotonergic dysfunction, negative mood states, and response to alcohol

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Dopamine transporter as target for drug development of cocaine dependence medications.

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Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner

1 reference

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12 December 2020

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Treatment of mood disorders

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Affinity and selectivity of matrix metalloproteinase inhibitors: a chemometrical study from the perspective of ligands and proteins

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Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin,

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Reboxetine: functional inhibition of monoamine transporters and nicotinic acetylcholine receptors

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Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

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Reduced levels of norepinephrine transporters in the locus coeruleus in major depression.

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Reboxetine: a selective norepinephrine reuptake inhibitor for the treatment of depression

1 reference

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Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters.

1 reference

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Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders

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Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors

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MOPAC: a semiempirical molecular orbital program

1 reference

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12 December 2020

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Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinit

1 reference

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Familial orthostatic tachycardia due to norepinephrine transporter deficiency

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Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors

1 reference

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Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype

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Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders

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Neurotransmitter transporters: recent progress

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Identifiers

10.1007/S10822-007-9146-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

DBLP publication ID

journals/jcamd/KharkarRD08

1 reference

DBLP Dataset 2021-01-02

28 January 2021

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060532%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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