Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential (Q46890865)

26 December 2017

title

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential (English)

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26 December 2017

author

Stefano Volinia

5

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26 December 2017

Carlo Maria Croce

12

object named as

C M Croce

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26 December 2017

S Semba

1

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26 December 2017

F Trapasso

2

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26 December 2017

M Fabbri

3

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26 December 2017

K A McCorkell

4

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26 December 2017

T Druck

6

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26 December 2017

D Iliopoulos

7

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26 December 2017

Y Pekarsky

8

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26 December 2017

H Ishii

9

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26 December 2017

P N Garrison

10

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26 December 2017

L D Barnes

11

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26 December 2017

K Huebner

13

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26 December 2017

language of work or name

English

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publication date

1 May 2006

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26 December 2017

published in

Oncogene

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26 December 2017

volume

25

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26 December 2017

issue

20

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26 December 2017

page(s)

2860-2872

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26 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209323

exact match

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cites work

Validating survivin as a cancer therapeutic target

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

21 January 2018

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Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein

21 January 2018

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Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

21 January 2018

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FHIT gene therapy prevents tumor development in Fhit-deficient mice.

21 January 2018

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Muir-Torre-like syndrome in Fhit-deficient mice

21 January 2018

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Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin Pathway

21 January 2018

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Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice

21 January 2018

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Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms

21 January 2018

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Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway

21 January 2018

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Cancer and the FRA3B/FHIT fragile locus: it's a HIT

21 January 2018

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Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

21 January 2018

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High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases

21 January 2018

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Control of apoptosis and mitotic spindle checkpoint by survivin

21 January 2018

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Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

21 January 2018

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Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

21 January 2018

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Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells

21 January 2018

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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

21 January 2018

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Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant

21 January 2018

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Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

21 January 2018

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Fhit is a physiological target of the protein kinase Src

21 January 2018

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Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines

21 January 2018

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Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9

21 January 2018

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Replacement of Fhit in cancer cells suppresses tumorigenicity

21 January 2018

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The FHIT gene 3p14.2 is abnormal in lung cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209323

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

21 January 2018

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Significance analysis of microarrays applied to the ionizing radiation response

21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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The tumor spectrum in FHIT-deficient mice

21 January 2018

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Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma

21 January 2018

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12 December 2020

Clonal genetic alterations in the lungs of current and former smokers

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12 December 2020

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

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12 December 2020

Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients.

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12 December 2020

Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.

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12 December 2020

The role of the FHIT/FRA3B locus in cancer

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12 December 2020

Role of FHIT in human cancer

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12 December 2020

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

1 reference

12 December 2020

Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus

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12 December 2020

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines

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12 December 2020

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

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12 December 2020

Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression

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12 December 2020

Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells

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12 December 2020

Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions

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12 December 2020

Identifiers

DOI

10.1038/SJ.ONC.1209323

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26 December 2017

PubMed ID

16407838

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26 December 2017