Regulation of human liver delta-aminolevulinic acid synthase by bile acids (Q46920273)

26 December 2017

title

Regulation of human liver delta-aminolevulinic acid synthase by bile acids (English)

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26 December 2017

author

Mihaela Zavolan

7

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author name string

Anne-Kathrin Peyer

1

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Diana Jung

2

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Markus Beer

3

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Carmela Gnerre

4

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Adrian Keogh

5

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Deborah Stroka

6

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Urs-A Meyer

8

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language of work or name

English

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publication date

1 December 2007

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26 December 2017

published in

Hepatology

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volume

46

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issue

6

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page(s)

1960-1970

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Porphyrins, porphyrin metabolism and porphyrias. I. Update

cites work

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Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH.

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Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).

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Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene

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Identification of the xenosensors regulating human 5-aminolevulinate synthase

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver

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Aligning multiple genomic sequences with the threaded blockset aligner

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LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process.

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Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

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Cytochrome P450: what have we learned and what are the future issues?

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FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

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Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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Redundant pathways for negative feedback regulation of bile acid production

21 January 2018

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Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

21 January 2018

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Hepatic porphyrins and urinary porphyrins and porphyrin precursors in liver cirrhosis.

21 January 2018

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Porphyrins, porphyrin metabolism and porphyrias. II. Diagnosis and monitoring in the acute porphyrias

21 January 2018

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7 January 2021

Recommendations for the diagnosis and treatment of the acute porphyrias

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7 January 2021

Analysis of bile acid-induced regulation of FXR target genes in human liver slices

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Pregnane X receptor is a target of farnesoid X receptor

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7 January 2021

Identifiers

DOI

10.1002/HEP.21879

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26 December 2017

PubMed ID

17975826

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26 December 2017