HtrA2 and Parkinson's disease: think PINK? (Q46920443)

26 December 2017

title

HtrA2 and Parkinson's disease: think PINK? (English)

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26 December 2017

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Emad S Alnemri

1

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26 December 2017

publication date

1 November 2007

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26 December 2017

published in

Nature Cell Biology

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26 December 2017

volume

9

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26 December 2017

issue

11

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26 December 2017

page(s)

1227-1229

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26 December 2017

The HtrA Family of Proteases

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

A PDZ switch for a cellular stress response

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

1 reference

https://api.crossref.org/works/10.1038%2FNCB1107-1227

7 January 2021

Identifiers

DOI

10.1038/NCB1107-1227

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26 December 2017

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26 December 2017