Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells (Q47114223)

http://europepmc.org/abstract/PMC/5685692

8 January 2018

title

Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells (English)

1 reference

http://europepmc.org/abstract/PMC/5685692

8 January 2018

1 reference

acute myeloid leukemia

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Krzysztof Poterlowicz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Alex Thompson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Mohamed El-Tanani

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Richard Morgan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Hardev S Pandha

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Guy R Simpson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ruth Pettengell

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Kevin Harrington

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

7 August 2017

1 reference

http://europepmc.org/abstract/PMC/5685692

8 January 2018

published in

Oncotarget

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

52

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

89566-89579

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

Targeting HOX/PBX dimers in cancer

10 June 2020

cites work

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Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage.

23 May 2018

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23 May 2018

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Necroptosis: Pathway diversity and characteristics

23 May 2018

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23 May 2018

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Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells

23 May 2018

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Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

23 May 2018

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23 May 2018

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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

PBX3 is an important cofactor of HOXA9 in leukemogenesis

23 May 2018

1 reference

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The role of HOX genes in normal hematopoiesis and acute leukemia.

23 May 2018

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From bortezomib to other inhibitors of the proteasome and beyond

23 May 2018

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Targeting the HOX/PBX dimer in breast cancer.

23 May 2018

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23 May 2018

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RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group

23 May 2018

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Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells

23 May 2018

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Targeting HOX and PBX transcription factors in ovarian cancer

23 May 2018

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HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer).

23 May 2018

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Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms

23 May 2018

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HOX expression patterns identify a common signature for favorable AML.

23 May 2018

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Identification of RIP1 kinase as a specific cellular target of necrostatins

23 May 2018

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HO-1 underlies resistance of AML cells to TNF-induced apoptosis

23 May 2018

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Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma.

23 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

MAP kinase signalling pathways in cancer

23 May 2018

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23 May 2018

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Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

23 May 2018

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23 May 2018

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23 May 2018

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23 May 2018

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Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

23 May 2018

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Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition.

23 May 2018

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Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

23 May 2018

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Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells.

15 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5685692

ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29163771

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.20023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29163771%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

29163771

1 reference