Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. (Q47193927)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

Coiled-coil domain containing 22

29 March 2020

main subject

1 reference

VPS26, retromer complex component A

1 reference

WASH complex subunit 2A

1 reference

VPS35 retromer complex component

1 reference

VPS26 endosomal protein sorting factor C

1 reference

VPS29 retromer complex component

1 reference

VPS35 endosomal protein sorting factor like

1 reference

Sorting nexin 17

1 reference

WASH complex subunit 2C

1 reference

Coiled-coil domain containing 93

1 reference

protein localization to endosome

1 reference

author

Florian Steinberg

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Kerrie E McNally

1

1 reference

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29 March 2020

Lindsey L Morris

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Brett M. Collins

17

1 reference

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29 March 2020

Imre Berger

18

1 reference

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29 March 2020

Ezra Burstein

20

1 reference

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29 March 2020

Peter J Cullen

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

19

Daniel D Billadeau

1 reference

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29 March 2020

author name string

Rebecca Faulkner

2

1 reference

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29 March 2020

Matthew Gallon

4

1 reference

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29 March 2020

Rajesh Ghai

5

1 reference

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29 March 2020

David Pim

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Paul Langton

7

1 reference

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29 March 2020

Neil Pearson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Chris M Danson

9

1 reference

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29 March 2020

Heike Nägele

10

1 reference

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29 March 2020

Amika Singla

12

1 reference

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29 March 2020

Brittany L Overlee

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Kate J Heesom

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Richard Sessions

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

Lawrence Banks

16

1 reference

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29 March 2020

publication date

11 September 2017

1 reference

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29 March 2020

1 reference

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29 March 2020

volume

19

1 reference

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29 March 2020

page(s)

1214-1225

1 reference

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29 March 2020

issue

10

1 reference

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https://scigraph.springernature.com/pub.10.1038/ncb3610

29 March 2020

exact match

0 references

cites work

Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Endocytic membrane trafficking and neurodegenerative disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

PANTHER version 10: expanded protein families and functions, and analysis tools.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Retromer and sorting nexins in endosomal sorting

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX17 regulates Notch pathway and pancreas development through the retromer-dependent recycling of Jag1.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Expansion of biological pathways based on evolutionary inference

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Retromer: a master conductor of endosome sorting

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Human papillomavirus L2 facilitates viral escape from late endosomes via sorting nexin 17.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

VPS35 mutations in Parkinson disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Assembly and solution structure of the core retromer protein complex

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

New baculovirus expression tools for recombinant protein complex production

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A FAM21-containing WASH complex regulates retromer-dependent sorting

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Functional architecture of the retromer cargo-recognition complex

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Protein complex expression by using multigene baculoviral vectors

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Generation of HPV pseudovirions using transfection and their use in neutralization assays.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Sorting nexin 17 facilitates LRP recycling in the early endosome

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Structural Mechanism for Cargo Recognition by the Retromer Complex.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5790113

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

14 August 2018

1 reference

Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCB3610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28892079%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

1 reference