Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children (Q47277659)

13 January 2018

title

Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children (English)

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13 January 2018

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M Wilda

1

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13 January 2018

J Bruch

2

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13 January 2018

L Harder

3

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13 January 2018

D Rawer

4

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A Reiter

5

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A Borkhardt

6

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W Woessmann

7

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13 January 2018

publication date

1 March 2004

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13 January 2018

published in

Leukemia

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13 January 2018

volume

18

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13 January 2018

page(s)

584-588

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issue

3

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403254

exact match

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cites work

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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Nucleolar Arf sequesters Mdm2 and activates p53

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

21 January 2018

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Role of genetic and epigenetic changes in Burkitt lymphoma

21 January 2018

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p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

p53 gene analysis in childhood B non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403254

inferred from DOI database lookup

7 January 2021

based on heuristic

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2403254

1 reference

13 January 2018

PubMed ID

14712292

1 reference

13 January 2018