p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53 (Q73897120)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11360201%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11360201%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

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1

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7 November 2019

Klas Wiman

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11360201%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

U Klangby

series ordinal

2

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7 November 2019

language of work or name

English

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publication date

1 April 2001

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7 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11360201%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

20

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7 November 2019

issue

17

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7 November 2019

page(s)

2171-2177

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204303

7 November 2019

exact match

0 references

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7 January 2021

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7 January 2021

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

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7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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7 January 2021

Activation of p53 in MDM2-overexpressing cells through phosphorylation

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p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia

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7 January 2021

Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma.

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7 January 2021

Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Multistep evolution of B-cell-derived tumors in humans and rodents

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Selective deletion of exon 1 beta of the p19ARF gene in metastatic melanoma cell lines.

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7 January 2021

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

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7 January 2021

Twist is a potential oncogene that inhibits apoptosis

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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7 January 2021

The INK4A/ARF locus and its two gene products

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7 January 2021

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

Biological activities of p53 mutants in Burkitt's lymphoma cells

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

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7 January 2021

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

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7 January 2021

Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021