Epsin-Dependent Ligand Endocytosis Activates Notch by Force. (Q47341755)

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5 April 2020

title

Epsin-Dependent Ligand Endocytosis Activates Notch by Force (English)

1 reference

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5 April 2020

main subject

Nicastrin Dmel_CG7012

1 reference

GOA release 2020-03-11

Delta Dmel_CG3619

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GOA release 2020-03-11

Notch Dmel_CG3936

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GOA release 2020-03-11

author name string

Paul D Langridge

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29195077%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Gary Struhl

series ordinal

2

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language of work or name

English

0 references

publication date

1 November 2017

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5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29195077%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

volume

171

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issue

6

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page(s)

1383-1396.e12

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The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand

5 April 2020

cites work

1 reference

12 December 2020

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

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Site-specific recombination between homologous chromosomes in Drosophila.

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Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye.

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Shear stress enhances the proteolysis of von Willebrand factor in normal plasma

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

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Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway

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Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.

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Limb development: marginal fringe benefits.

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Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis

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Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

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The scabrous protein can act as an extracellular antagonist of notch signaling in the Drosophila wing.

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

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Three-dimensional structure of human follicle-stimulating hormone

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Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

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Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

1 reference

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Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

1 reference

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Epsins: adaptors in endocytosis?

1 reference

12 December 2020

Direct observation of catch bonds involving cell-adhesion molecules

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Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion

1 reference

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EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.

1 reference

12 December 2020

Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts.

1 reference

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Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

1 reference

12 December 2020

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

1 reference

12 December 2020

Unidirectional Notch signaling depends on continuous cleavage of Delta

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12 December 2020

A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis

1 reference

12 December 2020

The adhesion force of Notch with Delta and the rate of Notch signaling

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Structure of human follicle-stimulating hormone in complex with its receptor

1 reference

12 December 2020

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.

1 reference

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Rab conversion as a mechanism of progression from early to late endosomes

1 reference

12 December 2020

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.

1 reference

12 December 2020

Internalization is required for proper Wingless signaling in Drosophila melanogaster

1 reference

12 December 2020

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

1 reference

12 December 2020

Structural basis for autoinhibition of Notch

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12 December 2020

Thirty-one flavors of Drosophila rab proteins.

1 reference

12 December 2020

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

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12 December 2020

The molecular logic of Notch signaling--a structural and biochemical perspective.

1 reference

12 December 2020

Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor

1 reference

12 December 2020

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice

1 reference

12 December 2020

Neuralized promotes basal to apical transcytosis of delta in epithelial cells

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12 December 2020

Mechanism and significance of cis-inhibition in Notch signalling.

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12 December 2020

Notch ligand ubiquitylation: what is it good for?

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12 December 2020

A screen for X-linked mutations affecting Drosophila photoreceptor differentiation identifies Casein kinase 1α as an essential negative regulator of wingless signaling

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12 December 2020

Notch ligand endocytosis: mechanistic basis of signaling activity

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12 December 2020

Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis

1 reference

12 December 2020

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

1 reference

12 December 2020

Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

1 reference

12 December 2020

Mechanisms by which von Willebrand disease mutations destabilize the A2 domain

1 reference

12 December 2020

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

1 reference

12 December 2020

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

1 reference

12 December 2020

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

1 reference

12 December 2020

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.

1 reference

12 December 2020

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force

1 reference

12 December 2020

10.1016/J.CELL.2017.10.048

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29195077%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

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5 April 2020

PubMed publication ID

29195077

1 reference