Trends in GPCR drug discovery: new agents, targets and indications. (Q47597808)

http://europepmc.org/abstract/MED/29075003

4 February 2018

title

Trends in GPCR drug discovery: new agents, targets and indications (English)

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13 May 2020

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5

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13 May 2020

Alexander S Hauser

1

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13 May 2020

author name string

Misty M Attwood

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6882681&resulttype=core&format=json

13 May 2020

Mathias Rask-Andersen

3

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13 May 2020

Helgi B Schiöth

4

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13 May 2020

publication date

27 October 2017

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http://europepmc.org/abstract/MED/29075003

4 February 2018

published in

Nature Reviews Drug Discovery

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6882681&resulttype=core&format=json

13 May 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6882681&resulttype=core&format=json

13 May 2020

page(s)

829-842

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13 May 2020

issue

12

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https://scigraph.springernature.com/pub.10.1038/nrd.2017.178

13 May 2020

exact match

0 references

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G protein-coupled receptors as therapeutic targets for multiple sclerosis

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Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

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Emerging paradigms in GPCR allostery: implications for drug discovery

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Recent updates on GPCR biased agonism.

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DrugBank 4.0: shedding new light on drug metabolism

21 January 2018

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Alignment-free $d_2^*$ oligonucleotide frequency dissimilarity measure improves prediction of hosts from metagenomically-derived viral sequences.

21 January 2018

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Open Targets: a platform for therapeutic target identification and validation

21 January 2018

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How many drug targets are there?

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Trends in the exploitation of novel drug targets

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A comprehensive map of molecular drug targets.

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Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

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Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial

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Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

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G protein-coupled receptors as targets for anti-diabetic therapeutics

21 January 2018

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Angiotensin II for the Treatment of Vasodilatory Shock

21 January 2018

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GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.

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Allosteric modulation and functional selectivity of G protein-coupled receptors.

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ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

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Development of allosteric modulators of GPCRs for treatment of CNS disorders

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Polypharmacology: challenges and opportunities in drug discovery

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Polypharmacology of dopamine receptor ligands.

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Proteomics. Tissue-based map of the human proteome

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7 January 2021

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Anatomical profiling of G protein-coupled receptor expression

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Novel Therapeutic GPCRs for Psychiatric Disorders

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRD.2017.178

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

21 January 2018

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Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis

21 January 2018

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The role of G protein-coupled receptors in the pathology of Alzheimer's disease

21 January 2018

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Serotonin 5-HT6 Receptor Antagonists in Alzheimer's Disease: Therapeutic Rationale and Current Development Status

21 January 2018

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The therapeutic potential of G-protein coupled receptors in Huntington's disease

21 January 2018

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Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial

21 January 2018

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Use of antidiabetic drugs in the U.S., 2003-2012.

21 January 2018

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Type 2 diabetes mellitus: a review of current trends

21 January 2018

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Once-Daily Liraglutide Versus Lixisenatide as Add-on to Metformin in Type 2 Diabetes: A 26-Week Randomized Controlled Clinical Trial.

21 January 2018

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Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.

21 January 2018

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GPR119: "double-dipping" for better glycemic control

21 January 2018

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G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges

21 January 2018

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Dopaminergic drugs in type 2 diabetes and glucose homeostasis.

21 January 2018

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G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

21 January 2018

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Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

21 January 2018

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International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

21 January 2018

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Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth.

21 January 2018

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Insights into bombesin receptors and ligands: Highlighting recent advances

21 January 2018

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Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice

21 January 2018

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Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

21 January 2018

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Galanin receptors as a potential target for neurological disease.

21 January 2018

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Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

21 January 2018

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

21 January 2018

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A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography

21 January 2018

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From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.

21 January 2018

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Structures of G protein-coupled receptors reveal new opportunities for drug discovery.

21 January 2018

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Editorial overview: New technologies: GPCR drug design and function — exploiting the current (of) structures

21 January 2018

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Structure-based discovery of opioid analgesics with reduced side effects

21 January 2018

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Pharmacology: Inside-out receptor inhibition.

21 January 2018

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Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists

21 January 2018

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G-protein-coupled receptors and signaling networks: emerging paradigms.

21 January 2018

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21 January 2018

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Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors

21 January 2018

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A Pluridimensional View of Biased Agonism

21 January 2018

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The dynamic process of β(2)-adrenergic receptor activation

21 January 2018

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A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

21 January 2018

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Biased Agonism of the Angiotensin II Type I Receptor

21 January 2018

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Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics

21 January 2018

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In vivo veritas, the next frontier for functionally selective GPCR ligands

21 January 2018

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Gut chemosensing mechanisms

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Commensal bacteria make GPCR ligands that mimic human signalling molecules

21 January 2018

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Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

21 January 2018

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Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

21 January 2018

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Extrasensory perception: odorant and taste receptors beyond the nose and mouth

21 January 2018

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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors

21 January 2018

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How Ligands Illuminate GPCR Molecular Pharmacology

21 January 2018

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Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

21 January 2018

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Cornerstones of CRISPR-Cas in drug discovery and therapy

21 January 2018

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Can you teach old drugs new tricks?

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21 January 2018

2016 FDA drug approvals

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Defining the brain circuits involved in psychiatric disorders: IMI-NEWMEDS.

31 March 2020

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A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks

31 March 2020

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

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GCRDb: a G-protein-coupled receptor database

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12 December 2020

Genome duplication events and functional reduction of ploidy levels in sturgeon (Acipenser, Huso and Scaphirhynchus)

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12 December 2020

Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression

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A Phase 2, Randomized, Dose-Finding Study of the Novel Once-Weekly Human GLP-1 Analog, Semaglutide, Compared With Placebo and Open-Label Liraglutide in Patients With Type 2 Diabetes

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The Latest Innovations in the Drug Pipeline for Multiple Sclerosis

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12 December 2020

Identifiers

DOI

10.1038/NRD.2017.178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6882681&resulttype=core&format=json

Dimensions Publication ID

13 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6882681&resulttype=core&format=json

13 May 2020

1 reference