How Ligands Illuminate GPCR Molecular Pharmacology (Q43757698)

26 November 2017

title

How Ligands Illuminate GPCR Molecular Pharmacology (English)

1 reference

G protein-coupled receptor

26 November 2017

main subject

0 references

1 reference

Raymond C Stevens

2

0 references

author name string

Daniel Wacker

series ordinal

1

1 reference

26 November 2017

Bryan L Roth

series ordinal

3

1 reference

26 November 2017

language of work or name

English

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publication date

1 July 2017

1 reference

26 November 2017

1 reference

26 November 2017

volume

170

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26 November 2017

issue

3

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26 November 2017

page(s)

414-427

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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

26 November 2017

cites work

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27 August 2018

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27 August 2018

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Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.

27 August 2018

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Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

27 August 2018

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The role of kinetic context in apparent biased agonism at GPCRs

27 August 2018

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The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

27 August 2018

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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

27 August 2018

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Comprehensive characterization of the Published Kinase Inhibitor Set

27 August 2018

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NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

27 August 2018

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Structural insights into µ-opioid receptor activation

27 August 2018

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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

27 August 2018

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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

27 August 2018

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27 August 2018

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27 August 2018

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27 August 2018

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27 August 2018

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27 August 2018

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The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo

27 August 2018

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27 August 2018

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27 August 2018

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27 August 2018

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

27 August 2018

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

27 August 2018

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Structure of class B GPCR corticotropin-releasing factor receptor 1

27 August 2018

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Structural Features for Functional Selectivity at Serotonin Receptors

27 August 2018

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Structural Basis for Molecular Recognition at Serotonin Receptors

27 August 2018

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Molecular signatures of G-protein-coupled receptors

27 August 2018

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From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands

27 August 2018

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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

27 August 2018

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Structure-function of the G protein-coupled receptor superfamily

27 August 2018

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27 August 2018

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A simple method for quantifying functional selectivity and agonist bias

27 August 2018

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

27 August 2018

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Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

27 August 2018

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27 August 2018

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

27 August 2018

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27 August 2018

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27 August 2018

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27 August 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

27 August 2018

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Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

27 August 2018

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

27 August 2018

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MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice

27 August 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

27 August 2018

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Strategies to discover unexpected targets for drugs active at G protein-coupled receptors

27 August 2018

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Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

27 August 2018

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1 rhodopsin mutations in congenital night blindness

27 August 2018

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Predicting new molecular targets for known drugs

27 August 2018

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

27 August 2018

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Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design.

27 August 2018

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Structure-based discovery of beta2-adrenergic receptor ligands

27 August 2018

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Temporally precise in vivo control of intracellular signalling

27 August 2018

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Prescription drug spending trends in the United States: looking beyond the turning point

27 August 2018

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Beta-arrestin-biased ligands at seven-transmembrane receptors

27 August 2018

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Drugs and valvular heart disease

27 August 2018

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Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

27 August 2018

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

27 August 2018

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Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

27 August 2018

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Transduction of receptor signals by beta-arrestins

27 August 2018

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ZINC--a free database of commercially available compounds for virtual screening

27 August 2018

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Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor

27 August 2018

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3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone

27 August 2018

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

27 August 2018

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Protein kinase inhibitors: insights into drug design from structure.

27 August 2018

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

27 August 2018

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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

27 August 2018

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Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist

27 August 2018

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Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor

27 August 2018

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Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

27 August 2018

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

27 August 2018

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Thrombin signalling and protease-activated receptors

27 August 2018

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Crystal structure of rhodopsin: A G protein-coupled receptor

27 August 2018

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Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

27 August 2018

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

27 August 2018

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Teratogen-mediated inhibition of target tissue response to Shh signaling

27 August 2018

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Three allosteric modulators act at a common site, distinct from that of competitive antagonists, at muscarinic acetylcholine M2 receptors.

27 August 2018

1 reference

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

27 August 2018

1 reference

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Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

27 August 2018

1 reference

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

27 August 2018

1 reference

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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

27 August 2018

1 reference

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Inverse agonist activity of beta-adrenergic antagonists.

27 August 2018

1 reference

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A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

27 August 2018

1 reference

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The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

27 August 2018

1 reference

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Operational models of pharmacological agonism.

27 August 2018

1 reference

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Opiate agonists and antagonists discriminated by receptor binding in brain

27 August 2018

1 reference

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Beta-adrenergic receptor kinase: primary structure delineates a multigene family

27 August 2018

1 reference

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

27 August 2018

1 reference

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Diversity of G proteins in signal transduction

27 August 2018

1 reference

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Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus

27 August 2018

1 reference

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The antagonism of acetyl choline by atropine

27 August 2018

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12 December 2020

Pharmacologic discrimination between receptor heterogeneity and allosteric interaction: resultant analysis of gallamine and pirenzepine antagonism of muscarinic responses in rat trachea

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12 December 2020

Trial watch: Opportunities and challenges of the 2016 target landscape

1 reference

12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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12 December 2020

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles

1 reference

12 December 2020

10.1016/J.CELL.2017.07.009

Identifiers

DOI

1 reference

26 November 2017

0 references

1 reference