Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells. (Q47599220)

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English	Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/27802439

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

author name string

Rajakrishnan Veluthakal

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

Daleep K Arora

2

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

Marc L Goalstone

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

Renu A Kowluru

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

Anjaneyulu Kowluru

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

publication date

2 November 2016

1 reference

Europe PubMed Central

PubMed publication ID

4 February 2018

http://europepmc.org/abstract/MED/27802439

Cellular Physiology and Biochemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

39

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

2110-2120

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tailoring Ras-pathway--inhibitor combinations for cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenylated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farnesyltransferase inhibitor as anticancer agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small G proteins in islet beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose activates prenyltransferases in pancreatic islet beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The perplexing case of the geranylgeranyl transferase-deficient mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein farnesylation and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting protein lipidation in disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A lack of 'glue' misplaces Rab27A to cause islet dysfunction in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein prenylation: unique fats make their mark on biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27802439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1159/000447907

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6685439&resulttype=core&format=json

11 May 2020

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