Angiopoietin-like 3 in lipoprotein metabolism. (Q47688043)

4 February 2018

title

Angiopoietin-like 3 in lipoprotein metabolism. (English)

1 reference

4 February 2018

1 reference

Sander Kersten

1

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4 February 2018

publication date

6 October 2017

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4 February 2018

Nature Reviews Endocrinology

published in

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4 February 2018

volume

13

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4 February 2018

page(s)

731-739

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4 February 2018

issue

12

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4 February 2018

https://scigraph.springernature.com/pub.10.1038/nrendo.2017.119

exact match

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Physiological regulation of lipoprotein lipase

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Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase

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Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia

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Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

21 January 2018

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ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

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Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene

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Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue

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Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue

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Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

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Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages

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Atypical angiopoietin-like protein that regulates ANGPTL3

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Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

21 January 2018

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Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

21 January 2018

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Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

21 January 2018

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ANGPTL8/betatrophin does not control pancreatic beta cell expansion

21 January 2018

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Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting

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RETRACTED: Betatrophin: a hormone that controls pancreatic β cell proliferation

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Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

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Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

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Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

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Angptl3 regulates lipid metabolism in mice

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Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.

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Hepatic proprotein convertases modulate HDL metabolism

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Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

21 January 2018

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Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes

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Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

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O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids

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A novel role of angiopoietin-like-3 associated with podocyte injury.

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Regulation of the angiopoietin-like protein 3 gene by LXR.

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Differential regulation and properties of angiopoietin-like proteins 3 and 4

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Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.

21 January 2018

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The lipoprotein lipase inhibitor ANGPTL3 is negatively regulated by thyroid hormone

21 January 2018

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ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states.

21 January 2018

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The acute phase response stimulates the expression of angiopoietin like protein 4.

21 January 2018

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Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR

21 January 2018

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Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes

21 January 2018

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Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

21 January 2018

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Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

21 January 2018

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A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

21 January 2018

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Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Hepatic ANGPTL3 regulates adipose tissue energy homeostasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Biological, clinical and population relevance of 95 loci for blood lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Characterization of three kindreds with familial combined hypolipidemia caused by loss-of-function mutations of ANGPTL3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Differential association of plasma angiopoietin-like proteins 3 and 4 with lipid and metabolic traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Identification of a novel mutation in the ANGPTL3 gene in two families diagnosed of familial hypobetalipoproteinemia without APOB mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

A form of familial hypobetalipoproteinaemia not due to a mutation in the apolipoprotein B gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.119

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28984319

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRENDO.2017.119

1 reference

4 February 2018

PubMed ID

28984319

1 reference

4 February 2018