Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein (Q47695462)

4 February 2018

title

Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein (English)

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4 February 2018

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T Tachibana

1

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4 February 2018

M Kato

2

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4 February 2018

T Watanabe

3

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4 February 2018

T Mitsui

4

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4 February 2018

Y Sugiyama

5

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4 February 2018

language of work or name

English

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publication date

1 June 2009

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4 February 2018

published in

Xenobiotica

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4 February 2018

volume

39

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4 February 2018

issue

6

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4 February 2018

page(s)

430-443

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4 February 2018

Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam.

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Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms.

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Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion

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Bicalutamide: clinical pharmacokinetics and metabolism

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Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

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FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

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Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo

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Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity

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Cimetidine and ranitidine increase midazolam bioavailability.

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Beneficial pharmacokinetic interaction between cyclosporine and itraconazole in renal transplant recipients

21 January 2018

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Triazolam Kinetics: Interaction with Cimetidine, Propranolol, and the Combination

21 January 2018

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The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

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Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro

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Differential impairment of triazolam and zolpidem clearance by ritonavir

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The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients

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In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids

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Pharmacokinetic interactions between two human immunodeficiency virus protease inhibitors, ritonavir and saquinavir

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Pharmacokinetic interactions between nelfinavir and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors atorvastatin and simvastatin

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Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

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The quantitative prediction of CYP-mediated drug interaction by physiologically based pharmacokinetic modeling

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Intestinal drug transporters: in vivo function and clinical importance.

21 January 2018

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Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes

21 January 2018

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Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

21 January 2018

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Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping

21 January 2018

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Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus

21 January 2018

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The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates

21 January 2018

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Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

21 January 2018

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Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe

21 January 2018

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Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

21 January 2018

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Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel

21 January 2018

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Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin

21 January 2018

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Concurrent administration of the erythromycin breath test (EBT) and oral midazolam as in vivo probes for CYP3A activity.

21 January 2018

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Effect of atorvastatin and fluvastatin on the metabolism of midazolam by cytochrome P450 in vitro

21 January 2018

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Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients

21 January 2018

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Interaction between FK506 and clotrimazole in a liver transplant recipient

21 January 2018

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

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In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach

21 January 2018

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Effect of ranitidine on the pharmacokinetics of triazolam and alpha-hydroxytriazolam in both young (19-60 years) and older (61-78 years) people

21 January 2018

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A potentially hazardous interaction between erythromycin and midazolam.

21 January 2018

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

21 January 2018

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Tacrolimus and cerivastatin pharmacokinetics and adverse effects after single and multiple dosing with cerivastatin in renal transplant recipients

21 January 2018

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Celiprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties and its therapeutic use in hypertension and angina pectoris

21 January 2018

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Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant

21 January 2018

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Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

21 January 2018

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Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria

21 January 2018

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Saquinavir, nelfinavir and M8 pharmacokinetics following combined saquinavir, ritonavir and nelfinavir administration.

21 January 2018

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

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Tacrolimus trough level adjustment after administration of fluconazole to kidney recipients

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250902846252

The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250902846252

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250902846252

Fluconazole, but not terbinafine, enhances the effects of triazolam by inhibiting its metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250902846252

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

Effects of metronidazole on midazolam metabolism in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250902846252

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

An integrated model for determining causes of poor oral drug absorption.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250902846252

10.1080/00498250902846252

21 January 2018

Identifiers

DOI

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4 February 2018

1 reference

4 February 2018