PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. (Q47802935)

5 February 2018

review article

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title

PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. (English)

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5 February 2018

author name string

A M Scharenberg

series ordinal

1

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5 February 2018

J P Kinet

series ordinal

2

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5 February 2018

language of work or name

English

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publication date

1 July 1998

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5 February 2018

published in

Cell

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5 February 2018

volume

94

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5 February 2018

issue

1

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5 February 2018

page(s)

5-8

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5 February 2018

Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

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Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

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Calcium signalling and cell proliferation

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SHIP modulates immune receptor responses by regulating membrane association of Btk.

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Differential activation of transcription factors induced by Ca2+ response amplitude and duration

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

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Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases.

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Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

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7 January 2021

Co-ligation of the antigen and Fc receptors gives rise to the selective modulation of intracellular signaling in B cells. Regulation of the association of phosphatidylinositol 3-kinase and inositol 5'-phosphatase with the antigen receptor complex

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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

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Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling

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The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release.

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Regulation of phosphoinositide-specific phospholipase C isozymes

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7 January 2021

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

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A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

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10.1016/S0092-8674(00)81214-3

Identifiers

DOI

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5 February 2018

PubMed ID

9674420

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5 February 2018