Use of pharmacological agents in elucidating the mechanism of insulin action (Q47834155)

6 February 2018

review article

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title

Use of pharmacological agents in elucidating the mechanism of insulin action (English)

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6 February 2018

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Srivastava AK

1

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6 February 2018

publication date

1 June 1998

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6 February 2018

Trends in Pharmacological Sciences

published in

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6 February 2018

volume

19

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6 February 2018

issue

6

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6 February 2018

page(s)

205-209

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6 February 2018

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

1 reference

7 January 2021

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Insulin action in cultured human myoblasts: contribution of different signalling pathways to regulation of glycogen synthesis.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

New connections in the regulation of PEPCK gene expression by insulin

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

A synthetic inhibitor of the mitogen-activated protein kinase cascade

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Insulin activates a PD 098059-sensitive kinase that is involved in the regulation of p70S6K and PHAS-I.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2898%2901208-5

7 January 2021

10.1016/S0165-6147(98)01208-5

Identifiers

DOI

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6 February 2018

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6 February 2018