Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation (Q47917268)

6 February 2018

title

Artesunate protects pancreatic beta cells against cytokine-induced damage via SIRT1 inhibiting NF-κB activation (English)

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6 February 2018

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L Yu

1

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6 February 2018

J F Chen

2

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X Shuai

3

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Y Xu

4

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Y Ding

5

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J Zhang

6

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6 February 2018

W Yang

7

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X Liang

8

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D Su

9

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C Yan

10

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publication date

11 June 2015

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6 February 2018

Journal of Endocrinological Investigation

published in

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6 February 2018

volume

39

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6 February 2018

issue

1

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6 February 2018

page(s)

83-91

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6 February 2018

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell

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Death and dysfunction of transplanted β-cells: lessons learned from type 2 diabetes?

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Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

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SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity

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Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways

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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential

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Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway

21 January 2018

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Artemisinin drugs: novel antimalarial agents

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Progress in research on the anti-tumor effect of artesunate

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The antiviral activities of artemisinin and artesunate.

21 January 2018

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Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria

21 January 2018

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Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic β-cells dysfunction

21 January 2018

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Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway

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Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells

21 January 2018

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The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

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Incretin-stimulated interaction between β-cell Kv1.5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SirT1.

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

21 January 2018

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Cytokines affect PDX-1 expression, insulin and proinsulin secretion from iNOS deficient murine islets

21 January 2018

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The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

21 January 2018

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Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

21 January 2018

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12 December 2020

Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes

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12 December 2020

Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria

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12 December 2020

Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.

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12 December 2020

Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis

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12 December 2020

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

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12 December 2020

10.1007/S40618-015-0328-1

Identifiers

DOI

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6 February 2018

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6 February 2018