ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis (Q47961195)

7 February 2018

review article

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title

ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis (English)

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7 February 2018

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Nicholson DW

1

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7 February 2018

publication date

1 March 1996

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7 February 2018

published in

Nature Biotechnology

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7 February 2018

volume

14

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7 February 2018

issue

3

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7 February 2018

page(s)

297-301

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7 February 2018

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

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Control of programmed cell death by the baculovirus genes p35 and iap.

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

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Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

21 January 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

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Involvement of an ICE-like protease in Fas-mediated apoptosis

21 January 2018

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Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

21 January 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

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Proteolysis of fodrin (non-erythroid spectrin) during apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNBT0396-297

Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNBT0396-297

Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNBT0396-297

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Inhibition of apoptosis by the expression of antisense Nedd2.

21 January 2018

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The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis.

21 January 2018

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Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

21 January 2018

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Isolation and partial characterization of a protease involved in Fas-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNBT0396-297

An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells

21 January 2018

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Structure and mechanism of interleukin-1 beta converting enzyme

21 January 2018

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Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

21 January 2018

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Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death

21 January 2018

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21 January 2018

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Apoptosis and its role in human disease

21 January 2018

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7 January 2021

The medical significance of physiological cell death.

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7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Analysis of the role of bcl-2 in apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Bcl-2 and Fas, molecules which influence apoptosis. A possible role in systemic lupus erythematosus?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Autoimmunity and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Expression of the baculovirus p35 gene inhibits mammalian neural cell death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Mechanisms and Functions of Cell Death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Molecular cloning of the interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Prevention of vertebrate neuronal death by the crmA gene

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

https://api.crossref.org/works/10.1038%2FNBT0396-297

7 January 2021

Identifiers

DOI

10.1038/NBT0396-297

1 reference

7 February 2018

1 reference

7 February 2018