Insulin signal transduction through protein kinase cascades. (Q48021735)

7 February 2018

review article

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title

Insulin signal transduction through protein kinase cascades. (English)

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7 February 2018

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J Avruch

1

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7 February 2018

publication date

1 May 1998

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7 February 2018

Molecular and Cellular Biochemistry

published in

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7 February 2018

volume

182

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7 February 2018

page(s)

31-48

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7 February 2018

issue

1-2

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7 February 2018

https://scigraph.springernature.com/pub.10.1023/a:1006823109415

exact match

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cites work

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

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12 December 2020

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

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Identification of the 14.3.3 zeta domains important for self-association and Raf binding

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p70s6k function is essential for G1 progression

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Nuclear localization of p85s6k: functional requirement for entry into S phase.

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Interaction of insulin with the cell membrane: the primary action of insulin

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The ras protein family: evolutionary tree and role of conserved amino acids

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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12 December 2020

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase

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12 December 2020

A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells

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12 December 2020

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase

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12 December 2020

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

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12 December 2020

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

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12 December 2020

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

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12 December 2020

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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12 December 2020

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

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12 December 2020

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

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12 December 2020

Function of Ras as a molecular switch in signal transduction

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12 December 2020

Kinase suppressor of Ras is ceramide-activated protein kinase

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12 December 2020

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

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12 December 2020

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro

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12 December 2020

Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways

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12 December 2020

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

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12 December 2020

Protein kinase cascades activated by stress and inflammatory cytokines

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12 December 2020

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

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12 December 2020

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12 December 2020

Effect of insulin on adenosine 3',5'-monophosphate in the rat epididymal fat pad

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12 December 2020

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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12 December 2020

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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12 December 2020

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo

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12 December 2020

PI3K: downstream AKTion blocks apoptosis

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12 December 2020

Protein prenylation: molecular mechanisms and functional consequences

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12 December 2020

Differential subcellular localisation of two isoforms of p70 S6 protein kinase.

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12 December 2020

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

12 December 2020

Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins

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12 December 2020

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12 December 2020

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1 reference

12 December 2020

Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6

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12 December 2020

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

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12 December 2020

Signal transduction via the MAP kinases: proceed at your own RSK.

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12 December 2020

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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12 December 2020

Protein kinase C alpha activates RAF-1 by direct phosphorylation

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12 December 2020

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

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12 December 2020

The insulin signaling system

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12 December 2020

Identification of the sites of interaction between c-Raf-1 and Ras-GTP

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12 December 2020

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

1 reference

12 December 2020

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

12 December 2020

Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.

1 reference

12 December 2020

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

1 reference

12 December 2020

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

12 December 2020

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

12 December 2020

Does mitogen-activated-protein kinase have a role in insulin action? The cases for and against

1 reference

12 December 2020

Insulin receptor signaling. Activation of multiple serine kinases

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12 December 2020

Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs

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12 December 2020

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

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12 December 2020

Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin-resistant humans

1 reference

12 December 2020

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

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12 December 2020

KSR, a novel protein kinase required for RAS signal transduction

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12 December 2020

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

12 December 2020

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1 reference

12 December 2020

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

1 reference

12 December 2020

Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells.

1 reference

12 December 2020

Activation of Jun kinase is an early event in hepatic regeneration

1 reference

12 December 2020

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

1 reference

12 December 2020

The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines

1 reference

12 December 2020

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.

1 reference

12 December 2020

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

12 December 2020

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

12 December 2020

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

1 reference

12 December 2020

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

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12 December 2020

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N

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12 December 2020

SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways

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12 December 2020

Function and regulation of ras.

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12 December 2020

Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

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12 December 2020

Purification of a hepatic S6 kinase from cycloheximide-treated Rats

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12 December 2020

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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12 December 2020

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

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12 December 2020

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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12 December 2020

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

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12 December 2020

Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes.

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12 December 2020

Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast-atom-bombardment mass spectrometry

1 reference

12 December 2020

Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3

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12 December 2020

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

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12 December 2020

How MAP kinases are regulated

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12 December 2020

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

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12 December 2020

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

1 reference

12 December 2020

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

1 reference

12 December 2020

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

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12 December 2020

Phosphoinositide kinases

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12 December 2020

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

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12 December 2020

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

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12 December 2020

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

12 December 2020

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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12 December 2020

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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12 December 2020

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

12 December 2020

Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase

1 reference

12 December 2020

The mitogen-activated protein kinase activator

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12 December 2020

Rho family members: activators of MAP kinase cascades.

1 reference

12 December 2020

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

12 December 2020

Structural and functional analysis of pp70S6k

1 reference

12 December 2020

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation

1 reference

12 December 2020

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

12 December 2020

A phosphotyrosine interaction domain

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12 December 2020

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

12 December 2020

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1 reference

12 December 2020

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

1 reference

12 December 2020

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

1 reference

12 December 2020

Insulin-signaling mechanisms. Lessons from the old testament of glycogen metabolism and the new testament of molecular biology

1 reference

12 December 2020

Glycogen synthase from rabbit skeletal muscle. State of phosphorylation of the seven phosphoserine residues in vivo in the presence and absence of adrenaline

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12 December 2020

New insights into the role and mechanism of glycogen synthase activation by insulin

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12 December 2020

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

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12 December 2020

The proliferation of MAP kinase signaling pathways in yeast.

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12 December 2020

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

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12 December 2020

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

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12 December 2020

Phosphatidylinositol-3-OH kinase as a direct target of Ras

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12 December 2020

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

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12 December 2020

Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation

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12 December 2020

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

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12 December 2020

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

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12 December 2020

Preferential stimulation of ribosomal protein synthesis by insulin and in the absence of ribosomal and messenger ribonucleic acid formation

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12 December 2020

Hormonal control of glycogen synthase in rat hemidiaphragms. Effects of insulin and epinephrine on the distribution of phosphate between two cyanogen bromide fragments

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12 December 2020

Identification of the major phosphorylation sites of the Raf-1 kinase.

1 reference

12 December 2020

Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity

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12 December 2020

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2

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12 December 2020

Mechanism of action of the immunosuppressant rapamycin

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12 December 2020

How receptor tyrosine kinases activate Ras.

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12 December 2020

Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue

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12 December 2020

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12 December 2020

An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ

1 reference

12 December 2020

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

12 December 2020

Activation of Raf-1 by 14-3-3 proteins

1 reference

12 December 2020

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

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12 December 2020

Raf-1 activates MAP kinase-kinase

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12 December 2020

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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12 December 2020

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

12 December 2020

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

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12 December 2020

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

1 reference

12 December 2020

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1 reference

12 December 2020

raf family serine/threonine protein kinases in mitogen signal transduction.

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12 December 2020

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

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12 December 2020

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

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12 December 2020

Proteins regulating Ras and its relatives

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12 December 2020

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1 reference

12 December 2020

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase

1 reference

12 December 2020

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

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12 December 2020

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

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12 December 2020

Signalling by receptor tyrosine kinases

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12 December 2020

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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12 December 2020

Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6

1 reference

12 December 2020

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

1 reference

12 December 2020

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

1 reference

12 December 2020

The effector interactions of p21ras

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12 December 2020

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

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12 December 2020

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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12 December 2020

Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf

1 reference

12 December 2020

Mitogen-activated protein kinase activation is not sufficient for stimulation of glucose transport or glycogen synthase in 3T3-L1 adipocytes

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12 December 2020

The stress-activated protein kinase subfamily of c-Jun kinases

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12 December 2020

Molecular cloning and expression of glycogen synthase kinase-3/factor A

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12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

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12 December 2020

Sounding the alarm: protein kinase cascades activated by stress and inflammation

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12 December 2020

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

12 December 2020

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

12 December 2020

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

1 reference

12 December 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

12 December 2020

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

12 December 2020

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

12 December 2020

Cyclic AMP-dependent activation of Rap1b

1 reference

12 December 2020

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

12 December 2020

Effects of epinephrine, diabetes, and insulin on rabbit skeletal muscle glycogen synthase. Phosphorylation site occupancies

1 reference

12 December 2020

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

12 December 2020

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1 reference

12 December 2020

Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

1 reference

12 December 2020

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

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12 December 2020

Multisite and hierarchal protein phosphorylation.

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12 December 2020

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

1 reference

12 December 2020

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

1 reference

12 December 2020

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1 reference

12 December 2020

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components

1 reference

12 December 2020

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1 reference

12 December 2020

Through thick and thin: wasting, obesity, and TNF alpha

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12 December 2020

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

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12 December 2020

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

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12 December 2020

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1006823109415

1 reference

7 February 2018

Dimensions Publication ID

0 references

1 reference

7 February 2018