Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. (Q48103560)

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12 March 2020

title

Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode (English)

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12 March 2020

2

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12 March 2020

author name string

Baobin Li

series ordinal

1

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12 March 2020

Lei Lu

series ordinal

3

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12 March 2020

Jiaoyang Jiang

series ordinal

4

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12 March 2020

publication date

20 March 2017

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Nature Structural & Molecular Biology

12 March 2020

published in

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12 March 2020

volume

24

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12 March 2020

issue

4

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12 March 2020

page(s)

362-369

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O-GlcNAc profiling: from proteins to proteomes

12 March 2020

cites work

1 reference

A little sugar goes a long way: the cell biology of O-GlcNAc

21 January 2018

1 reference

Nutrient regulation of signaling, transcription, and cell physiology by O-GlcNAcylation.

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O-GlcNAc and the epigenetic regulation of gene expression

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O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation

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HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase

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Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition

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O-GlcNAc modification: a nutritional sensor that modulates proteasome function

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Protein ubiquitination is modulated by O-GlcNAc glycosylation

21 January 2018

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Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes

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Protein O-GlcNAcylation in diabetes and diabetic complications

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The emerging link between O-GlcNAc and Alzheimer disease.

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O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

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O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

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Cancer metabolism and elevated O-GlcNAc in oncogenic signaling

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Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats

21 January 2018

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Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain

21 January 2018

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The active site of O-GlcNAc transferase imposes constraints on substrate sequence

21 January 2018

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Structure of human O-GlcNAc transferase and its complex with a peptide substrate

21 January 2018

1 reference

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

21 January 2018

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Human OGA binds substrates in a conserved peptide recognition groove

21 January 2018

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O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

21 January 2018

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O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?

21 January 2018

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Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

21 January 2018

1 reference

Three-dimensional structure of aStreptomyces sviceusGNAT acetyltransferase with similarity to the C-terminal domain of the human GH84O-GlcNAcase

21 January 2018

1 reference

Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities

21 January 2018

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A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome

21 January 2018

1 reference

Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate

21 January 2018

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O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

1 reference

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

21 January 2018

1 reference

Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

21 January 2018

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Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

21 January 2018

1 reference

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

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Visualizing the reaction coordinate of an O-GlcNAc hydrolase

21 January 2018

1 reference

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

21 January 2018

1 reference

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

21 January 2018

1 reference

Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

21 January 2018

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Chemical approaches to study O-GlcNAcylation

21 January 2018

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GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

21 January 2018

1 reference

Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants

21 January 2018

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Inference of macromolecular assemblies from crystalline state

21 January 2018

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

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Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation

21 January 2018

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Quantum mechanical/molecular mechanical molecular dynamics simulation of wild-type and seven mutants of CpNagJ in complex with PUGNAc.

21 January 2018

1 reference

Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Coot: model-building tools for molecular graphics

21 January 2018

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PHENIX: building new software for automated crystallographic structure determination

21 January 2018

1 reference

The CCP4 suite: programs for protein crystallography

21 January 2018

1 reference

Real-time measurements of dark substrate catalysis

21 January 2018

1 reference

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation

21 January 2018

1 reference

Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum

31 March 2020

1 reference

Sedimentation equilibrium as thermodynamic tool

31 March 2020

1 reference

O-GlcNAc signaling in cancer metabolism and epigenetics

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28319083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isoforms of human O-GlcNAcase show distinct catalytic efficiencies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28319083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Topography and polypeptide distribution of terminal N-acetylglucosamine residues on the surfaces of intact lymphocytes. Evidence for O-linked GlcNAc

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28319083

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.3390

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28319083%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference